Artikel Ilmiah : I1C021001 a.n. RENI SULIS SETIYAWATI
| NIM | I1C021001 |
|---|---|
| Namamhs | RENI SULIS SETIYAWATI |
| Judul Artikel | KAJIAN KETEPATAN TERAPI ANTIBIOTIK DEFINITIF DAN CLINICAL OUTCOME PADA PASIEN DEWASA DENGAN HOSPITAL ACQUIRED PNEUMONIA DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO |
| Abstrak (Bhs. Indonesia) | Hospital-acquired pneumonia (HAP) merupakan infeksi saluran napas bawah yang muncul ≥48 jam setelah pasien dirawat di rumah sakit dan berdampak signifikan terhadap morbiditas serta mortalitas. Penelitian ini bertujuan mengevaluasi ketepatan pemilihan dan pendosisan antibiotik definitif serta hubungannya dengan clinical outcome pasien HAP dewasa di RSUD Prof. Dr. Margono Soekarjo Purwokerto dengan desain observasional deskriptif analitik retrospektif menggunakan data rekam medis periode Januari–Desember 2024. Ketepatan terapi dievaluasi berdasarkan hasil kultur bakteri dan kesesuaian dengan pedoman IDSA (2016), PNPK (2023), serta DIH (2021), dan dianalisis secara univariat serta bivariat menggunakan uji Chi-square dengan tingkat signifikansi 5%. Dari 35 sampel, ditemukan 62 regimen antibiotik mayoritas berupa monoterapi (82,4%) dengan meropenem paling sering digunakan, ketepatan berdasarkan hasil kultur sebesar 48,6%, berdasarkan guideline 24,2%, dan ketepatan dosis 44,3%. Sebanyak 53,2% pasien tercatat mengalami perbaikan klinis, di mana pasien yang mendapat terapi tepat cenderung memiliki outcome klinis lebih baik, meskipun hubungan ini tidak signifikan secara statistik (p>0,05). Hasil ini menunjukkan perlunya optimalisasi penggunaan antibiotik berbasis kultur dan guideline untuk meningkatkan efektivitas terapi serta mencegah resistensi antimikroba. |
| Abtrak (Bhs. Inggris) | Hospital-acquired pneumonia (HAP) is a lower respiratory tract infection occurring ≥48 hours after hospitalization, increasing morbidity and mortality. This descriptive-analytic observational retrospective study aimed to evaluate the appropriateness of definitive antibiotic selection and dosing and its relationship with clinical outcomes in adult HAP patients at RSUD Prof. Dr. Margono Soekarjo Purwokerto using medical records from January to December 2024. Appropriateness was assessed based on bacterial culture results and guidelines (IDSA 2016, PNPK 2023, DIH 2021), with univariate and bivariate analysis using the Chi-square test at a 5% significance level. Among 35 samples with 62 antibiotic regimens, most antibiotics were given as monotherapy (82.4%), with meropenem being most frequently used. Appropriateness of definitive antibiotics was 48.6% based on culture, 24.2% based on guidelines, and 44.3% for dosing accuracy. Clinical improvement was observed in 53.2% of patients, with a trend toward better outcomes in those receiving appropriate antibiotics, although no statistically significant relationship was found (p > 0.05). These results indicate that while the appropriateness of definitive antibiotic therapy was relatively low, rational antibiotic use remains crucial to improve outcomes and prevent resistance. |
| Kata kunci | Hospital-acquired pneumonia, antibiotik definitif, guideline terapi, clinical outcome, terapi rasional |
| Pembimbing 1 | Dr. apt. Esti Dyah Utami, M,Sc. |
| Pembimbing 2 | apt. Vitis Vini Fera Ratna Utami, M,Sc. |
| Pembimbing 3 | |
| Tahun | 2025 |
| Jumlah Halaman | 10 |
| Tgl. Entri | 2025-07-09 12:11:15.15549 |