Artikel Ilmiah : G1A021006 a.n. PITRA GUNA ALAMSYAH
| NIM | G1A021006 |
|---|---|
| Namamhs | PITRA GUNA ALAMSYAH |
| Judul Artikel | PERBANDINGAN EFEK SAMPING TENOFOVIR DAN ENTECAVIR TERHADAP FUNGSI GINJAL PADA PASIEN HEPATITIS B KRONIS DI RSUD MARGONO SOEKARJO |
| Abstrak (Bhs. Indonesia) | Latar Belakang : Hepatitis B kronis merupakan ancaman bagi masyarakat di dunia. Di Indonesia, Riset Kesehatan Dasar (Riskesdas) 2017 menyebutkan bahwa pasien hepatitis B kronis mencapai 10%. Tujuan : Penelitian ini bertujuan untuk menganalisis perbedaan efek samping tenofovir dan entecavir terhadap kadar ureum dan kreatinin pada pasien hepatitis B kronis di RSUD Margono Soekarjo. Metode : Penelitian ini termasuk observasional analitik dengan mengumpulkan sebanyak 70 pasien hepatitis B kronis yang mendapatkan terapi tenofovir atau entecavir. Data dikumpulkan dari rekam medis RSUD Margono Soekarjo mulai dari Januari sampai Oktober 2024. Hasil : rata-rata usia pasien hepatitis B kronis di RSUD Margono Soekarjo adalah 37,97 tahun. Pasien didominasi oleh laki-laki sebanyak 39 pasien (55,7%). Hasil uji fisher exact menunjukkan adanya perbedaan efek samping tenofovir dan entecavir terhadap ureum dengan nilai p 0,025. Hasil uji chi-square menunjukkan terdapat perbedaan efek samping tenofovir dan entecavir terhadap kadar kreatinin dengan p-value sebesar 0,040. Tenofovir cenderung menyebabkan peningkatan kadar ureum dan kreatinin. Kesimpulan : Terdapat perbedaan efek samping tenofovir dan entecavir terhadap kadar ureum dan kreatinin pada pasien hepatitis B kronis di RSUD Margono Soekarjo setelah 6 bulan pengobatan. Klinisi disarankan untuk lebih berhati-hati dalam pengobatan tenofovir dan diperlukan pemantauan secara rutin |
| Abtrak (Bhs. Inggris) | Background: Chronic Hepatitis B is a threat to people in the world. In Indonesia, Riset Kesehatan Dasar (Riskesdas) 2017 stated that chronic hepatitis B patients reached 10%. Objective : This study aims to analyze the difference in the side effects of tenofovir and entecavir on urea and creatinine levels in chronic hepatitis B patients at Margono Soekarjo Hospital. Methods: This study included observational analysis by collecting as many as 70 chronic hepatitis B patients who received tenofovir or entecavir therapy. Data was collected from the medical records of Margono Soekarjo Hospital from January to October 2024. Results: The average age of chronic hepatitis B patients at Margono Soekarjo Hospital was 37.97 years. Patients were dominated by men as many as 39 patients (55.7%). The results of the Fisher Exact test showed that there was a difference in the side effects of tenofovir and entecavir on urea with a p value of 0.025. The results of the chi-square test showed that there was a difference in the side effects of tenofovir and entecavir on creatinine levels with a pvalue of 0.040. Tenofovir tends to cause increased levels of urea and creatinine. Conclusion: There are differences in the side effects of tenofovir and entecavir on urea and creatinine levels in chronic hepatitis B patients at Margono Soekarjo Hospital after 6 months of treatment. Clinicians are advised to be more careful in the treatment of tenofovir and routine monitoring is required |
| Kata kunci | Entecavir, Hepatitis B kronis, Kreatinin, Nefrotoksik, Tenofovir, Ureum |
| Pembimbing 1 | Dr. dr. Eman Sutrisna, M. Kes |
| Pembimbing 2 | dr. Suharno, Sp. PD-KGEH |
| Pembimbing 3 | |
| Tahun | 2025 |
| Jumlah Halaman | 12 |
| Tgl. Entri | 2025-01-15 10:03:19.254484 |