| Abstrak (Bhs. Indonesia) | Latar Belakang: Talasemia beta minor dan anemia defisiensi besi (ADB) merupakan penyebab tersering anemia mikrositik hipokromik dengan gambaran laboratorium serupa namun tatalaksana berbeda. Indeks Ricerca adalah metode skrining sederhana berbasis RDW dan RBC untuk membedakan keduanya. Tujuan: Menganalisis cut-off optimal, sensitivitas, spesifisitas, positive predictive value (PPV), negative predictive value (NPV), dan akurasi diagnostik indeks Ricerca. Metode: Penelitian observasional analitik cross-sectional dengan consecutive sampling menggunakan data sekunder 80 pasien (40 talasemia beta minor, 40 ADB) usia ≤18 tahun periode 2020-2025. Indeks Ricerca dihitung dengan RDW/RBC dan dianalisis menggunakan kurva Receiver Operating Characteristic (ROC). Hasil: Terdapat perbedaan signifikan distribusi usia, Hb, RBC, dan indeks Ricerca (ρ<0,001). Cut-off optimal <4,3 untuk talasemia beta minor dan >4,3 untuk ADB. Area Under the Curve (AUC) 0,861 (95% CI: 0,776-0,945; ρ<0,001). Sensitivitas, spesifisitas, PPV, NPV untuk talasemia beta minor: 77,50%; 80,00%; 79,49%; 78,05%, untuk ADB: 80,00%; 77,50%; 78,05%; 79,49%, indeks Youden 0,58. Kesimpulan: Indeks Ricerca memiliki performa diagnostik baik dengan akurasi 86,1% untuk skrining talasemia beta minor dan ADB. |
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| Abtrak (Bhs. Inggris) | Background: Beta thalassemia minor and iron deficiency anemia (IDA) are common causes of microcytic hypochromic anemia with similar laboratory features but different management. The Ricerca index is a simple screening method based on RDW and RBC to differentiate them. Objective: To analyze optimal cut-off, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of Ricerca index. Methods: Analytical observational cross-sectional study with consecutive sampling using secondary data from 80 patients (40 beta thalassemia minor, 40 IDA) aged ≤18 years during 2020-2025. Ricerca index was calculated using RDW/RBC and analyzed using Receiver Operating Characteristic (ROC) curve. Results: Significant differences were found in age distribution, Hb, RBC, and Ricerca index (ρ<0.001). Optimal cut-off was <4.3 for beta thalassemia minor and >4.3 for IDA. Area Under the Curve (AUC) was 0.861 (95% CI: 0.776-0.945; ρ<0.001). Sensitivity, specificity, PPV, NPV for beta thalassemia minor: 77.50%; 80.00%; 79.49%; 78.05%, for IDA: 80.00%; 77.50%; 78.05%; 79.49%, Youden index 0.58. Conclusion: Ricerca index has good diagnostic performance with 86.1% accuracy for screening beta thalassemia minor and IDA. |
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