| Abstrak (Bhs. Indonesia) | Latar belakang: Diabetes melitus tipe 2 (DMT2) dapat disertai inflamasi yang ditandai dengan peningkatan kadar CRP. Tujuan: Menganalisis efek pemberian kefir susu kambing berbagai dosis terhadap kadar C-Reactive Protein (CRP) pada tikus Wistar model DMT2. Metode: Penelitian ini menggunakan metode true experimental dengan rancangan posttest only with control group design. Tiga puluh ekor tikus dibagi menjadi lima kelompok secara acak. Kelompok A sebagai kontrol sehat, kelompok B sebagai kontrol sakit dengan induksi HFD-STZ, kelompok perlakuan C, D, E dengan induksi HFD-STZ yang diberi kefir susu kambing selama 28 hari dengan dosis 1,05, 2,1, dan 4,2 mL/200gBB/hari. Hasil: Rerata kadar CRP (ng/mL) pada setiap kelompok tikus, yaitu kelompok A = 3,64±0,38; kelompok B = 4,28±0,37; kelompok C = 4,57±0,53; kelompok D = 3,81±0,55; kelompok E = 3,80±0,50. Hasil uji parametrik One Way ANOVA didapatkan nilai p = 0,031 yang menunjukkan bahwa terdapat perbedaan kadar CRP yang signifikan antar kelompok. Uji Post Hoc Tukey HSD menunjukkan perbedaan signifikan hanya ditemukan antara kelompok A dengan C. Tidak terdapat perbedaan bermakna antara kelompok A dengan kelompok perlakuan dosis 2,1 mL (D) maupun dosis 4,2 mL (E). Kesimpulan: Kefir susu kambing tidak berpengaruh secara signifikan terhadap kadar CRP tikus putih Galur Wistar (Rattus norvegicus) model DMT2. Namun, dosis 2,1 mL dan 4,2 mL per 200 gBB/hari menunjukkan tren perbaikan kadar CRP yang lebih mendekati kelompok sehat dibandingkan kelompok sakit |
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| Abtrak (Bhs. Inggris) | Background: Type 2 diabetes mellitus (T2DM) may be accompanied by liver dysfunction reflected by altered transaminase enzymes. Objective: To analyze the effects of different doses of goat milk kefir on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in a T2DM Wistar rat model. Methods: This study used a true experimental method with a posttest-only control group design. Thirty male Wistar rats were randomly divided into five groups: healthy control (A), diabetic control induced by HFD-STZ (B), and treatment groups (C, D, E) induced with HFD-STZ and administered goat milk kefir at doses of 1.05, 2.1, and 4.2 mL/200 gBW/day for 28 days. Results: Mean CRP levels (ng/mL) in each group were as follows: A = 3.64 ± 0.38, B = 4.28 ± 0.37, C = 4.57 ± 0.53, D = 3.81 ± 0.55, and E = 3.80 ± 0.50. One-Way ANOVA showed a significant difference among groups (p = 0.031). Post Hoc Tukey HSD test revealed a significant difference only between group A and group C (p < 0.05). No significant differences were found between the diabetic control group (B) and treatment groups D or E (p > 0.05), although groups D and E demonstrated a trend of decreased CRP levels approaching the healthy control group. Conclusion: Goat milk kefir did not significantly reduce CRP levels in Wistar rats (Rattus norvegicus) with T2DM. However, kefir at doses of 2.1 and 4.2 mL/200 gBW/day showed a non-significant trend toward improving CRP levels compared to the diabetic control group |
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