Artikel Ilmiah : I2A022012 a.n. IMAH NUR CHASANAH
| NIM | I2A022012 |
|---|---|
| Namamhs | IMAH NUR CHASANAH |
| Judul Artikel | Analisis Survival Dan Faktor Risiko Kematian Pasien Covid-19 (Studi di RSUD Prof. Dr. Margono Soekarjo Purwokerto) |
| Abstrak (Bhs. Indonesia) | Kasus kematian pasien COVID-19 di RSUD Prof. Dr. Margono Soekarjo tertinggi di kabupaten Banyumas. Kematian pasien COVID-19 yang dirawat di rumah sakit dipengaruhi oleh berbagai faktor. Penelitian ini bertujuan untuk menggali faktor risiko kematian pada pasien COVID-19 menggunakan pendekatan analisis survival. Penelitian ini merupakan penelitian analitik observasional menggunakan desain kohort. Data penelitian bersumber dari rekam medis pasien COVID-19 bulan September 2021 yang dirawat di RSUD Prof. Dr. Margono Soekarjo Purwokerto.. Analisis life table dan kurva kaplan meier digunakan untuk mengetahui ketahanan hidup pasien. Analisis multivariat menggunakan cox regression time independent digunakan untuk mengetahui faktor yang berpengaruh terhadap kematian pasien, dan mendapatkan nilai hazard ratio. Hasil dianggap sinifikan apabila nilai p < 0,05. Hasil penelitian menunjukkan terdapat 169 pasien COVID-19, terdiri dari 100 perempuan, dan 69 laki-laki. Mayoritas berusia < 60 tahun, dan berstatus menikah (75,15%). Sebagian besar memiliki saturasi oksigen ≥ 93%, memiliki komorbid (81,1%), sebanyak 75,15% memiliki tingkat keparahan ringan-sedang. Rata-rata kadar D-dimer 3802,8 ng/ml, kadar neutrofil-limfosit ratio 8,4, neutrofil 75,5%, leukosit 11713 ng/mL, dan limfosit 16,1%. Ketahanan hidup pasien selama 30 hari sebesar 0,64. Faktor yang berpengaruh signifikan terhadap kematian pasien COVID-19 yaitu kadar D-dimer ≥ 2.390 ng/ml (p = 0.001; HR = 3.89), dan tingkat keparahan penyakit berat-kritis (p = 0,009; HR = 2,71). Faktor lain seperti usia, komorbid, saturasi oksigen, kadar D-dimer, kadar leukosit, kadar limfosit, kadar NLR tidak berpengaruh. Berdasarkan hasil penelitian, maka pasien COVID-19 yang memiliki kadar D-dimer ≥ 2.390 ng/ml dan/atau berada pada tingkat keparahan berat-kritis perlu diprioritaskan untuk mendapatkan penanganan medis sehingga risiko kematiannya dapat ditekan. |
| Abtrak (Bhs. Inggris) | The highest number of COVID-19 patient deaths occurred at Prof. Dr. Margono Soekarjo General Hospital in Banyumas Regency. The mortality of COVID-19 patients treated in hospitals is influenced by various factors. This study aims to explore the risk factors for mortality in COVID-19 patients using a survival analysis approach. This research is an observational analytic study using a cohort design. The research data were sourced from the medical records of COVID-19 patients in September 2021 who were treated at Prof. Dr. Margono Soekarjo General Hospital in Purwokerto. Life table analysis and Kaplan-Meier curves were used to determine patient survival. Multivariate analysis using time-independent Cox regression was used to identify factors that significantly influence mortality and to obtain hazard ratio values. Results were considered significant if the p-value < 0.05. The study results showed that there were 169 COVID-19 patients, consisting of 100 females and 69 males. The majority were under 60 years of age and married (75.15%). Most had an oxygen saturation of ≥ 93%, had comorbidities (81.1%), and 75.15% had mild to moderate severity. The average D-dimer level was 3802.8 ng/ml, neutrophil-lymphocyte ratio was 8.4, neutrophil level was 75.5%, leukocyte count was 11713 ng/mL, and lymphocyte level was 16.1%. The 30-day survival rate of patients was 0.64. Factors significantly influencing COVID-19 patient mortality were D-dimer levels ≥ 2,390 ng/ml (p = 0.001; HR = 3.89) and severe-critical disease severity (p = 0.009; HR = 2.71). Other factors such as age, comorbidities, oxygen saturation, leukocyte levels, lymphocyte levels, and NLR levels did not have a significant impact. Based on the research findings, COVID-19 patients with D-dimer levels ≥ 2,390 ng/ml and/or severe-critical disease severity need to be prioritized for medical treatment to reduce the risk of death. Keyword : COVID-19, D-dimer, severe-critical, time to death |
| Kata kunci | COVID-19, D-dimer, severe-critical, time to death |
| Pembimbing 1 | Siwi Pramatama Mars Wijayanti, S.Si.,M.Kes.,Ph.D |
| Pembimbing 2 | Prof. Dr. Dwi Sarwani Sri Rejeki, M.Kes(Epid) |
| Pembimbing 3 | - |
| Tahun | 2024 |
| Jumlah Halaman | 22 |
| Tgl. Entri | 2024-07-25 10:43:34.210787 |