| NIM | I1C019006 |
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| Namamhs | ISWATUN KHASANAH |
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| Judul Artikel | FORMULASI CLAY MASK EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP Propionibacterium acnes |
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| Abstrak (Bhs. Indonesia) | Jerawat merupakan penyakit inflamasi yang mempengaruhi folikel pilosebasea kulit. Salah satu penyebab jerawat tersebut yaitu terjadinya kolonisasi mikroba dengan Propionibacterium acnes. Penelitian ini bertujuan untuk memformulasikan clay mask ekstrak etanol daun belimbing wuluh dengan beberapa konsentrasi yang memenuhi persyaratan sifat fisik dan stabilitas serta memiliki aktivitas antibakteri terhadap Propionibacterium acnes. Sediaan clay mask dibuat dengan variasi konsentrasi ekstrak sebesar 5%, 10% dan 15%. Sediaan clay mask diuji sifat fisik dan stabilitas fisik meliputi organoleptis, homogenitas, pH, viskositas, daya lekat, daya sebar dan stabilitas freeze-thaw. Formula terpilih diuji aktivitas antibakteri dengan metode difusi sumuran dan diameter zona hambat dianalisis dengan dibandingkan terhadap kontrol positif dan kontrol negatif. Semua formulasi clay mask memenuhi kriteria evaluasi mutu fisik dan stabilitas. Formula clay mask ekstrak etanol daun belimbing wuluh pada konsentrasi 5%, 10% dan 15% memiliki aktivitas antibakteri terhadap Propionibacterium acnes dimana semakin banyak ekstrak, semakin kuat zona hambat yang dihasilkan. Clay mask ekstrak etanol daun belimbing wuluh konsentrasi 15% memiliki aktivitas antibakteri paling baik terhadap Propionibacterium acnes sebesar 12,33 dan 10,17 mm dengan kategori kuat. |
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| Abtrak (Bhs. Inggris) | Acne is an inflammatory disease that affects the pilosebaceous follicles of the skin. One of the causes of acne is the colonization of microbes with Propionibacterium acnes. This study aims to formulate clay mask ethanol extract of belimbing wuluh leaves with several concentrations that meet the requirements for physical properties and stability and have antibacterial activity against Propionibacterium acnes. Clay mask preparations were made with variations in extract concentrations of 5%, 10% and 15%. The clay mask preparations were tested for physical properties and physical stability including organoleptic, homogeneity, pH, viscosity, adhesion, spreadability and freeze-thaw stability. The selected formula was tested for antibacterial activity using the well-diffusion method and the diameter of the inhibition zone was analyzed by comparison with the positive control and negative control. All clay mask formulations met the evaluation criteria for physical quality and stability. Clay mask formula with ethanol extract of belimbing wuluh leaves at a concentration of 5%, 10% and 15% has antibacterial activity against Propionibacterium acnes where the more extract, the stronger the inhibition zone is produced. Clay mask ethanol extract of belimbing wuluh leaves concentration of 15% has the best antibacterial activity against Propionibacterium acnes of 12.33 and 10.17 mm in the strong category. |
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| Kata kunci | Clay mask, Ethanol Extract of Belimbing Wuluh Leaves (Averrhoa bilimbi L.), Propionibacterium acnes |
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| Pembimbing 1 | Drs. Sunarto MS., MP. |
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| Pembimbing 2 | Dr. apt. Eka Prasasti Nur Rachmani, M.Sc. |
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| Pembimbing 3 | |
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| Tahun | 2023 |
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| Jumlah Halaman | 11 |
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| Tgl. Entri | 2023-05-13 11:13:44.395036 |
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