Artikel Ilmiah : I1C018051 a.n. LUTVI ENDRIYANA
| NIM | I1C018051 |
|---|---|
| Namamhs | LUTVI ENDRIYANA |
| Judul Artikel | HUBUNGAN ESTIMASI KADAR OBAT GENTAMISIN DALAM DARAH TERHADAP CLINICAL OUTCOME PASIEN PNEUMONIA ANAK |
| Abstrak (Bhs. Indonesia) | Latar Belakang: Gentamisin merupakan salah satu antibiotik empiris yang digunakan sebagai terapi lini pertama pneumonia berat pada anak. Gentamisin termasuk antibiotik indeks terapi sempit, sehingga jika adanya perubahan sejumlah kecil kadar obat dapat menyebabkan efek samping yang tidak diinginkan atau dapat menimbulkan efek toksik. Penelitian ini bertujuan untuk mengetahui hubungan kadar gentamisin terhadap clinical outcome pasien pneumonia anak. Metodologi: Penelitian ini merupakan penelitian observasional dengan pengambilan data secara retrospektif. Pengambilan data dilakukan pada rekam medis pasien anak pneumonia rawat inap periode Januari-Desember 2020 di Rumah Sakit Margono Soekarjo Purwokerto. Data penelitian dianalisis secara univariat dengan perhitungan pendekatan farmakokinetika dan bivariat dengan uji fisher untuk mengetahui hubungan antara estimasi kadar gentamisin terkait rentang terapi dan rasio Cmax/MIC terhadap clinical outcome pasien. Hasil Penelitian: Sebanyak 33 pasien berada dalam kriteria inklusi. Terdapat 31 pasien dengan hasil estimasi kadar berada dalam rentang terapi dimana 7 pasien menunjukkan clinical outcome baik dan 24 pasien dengan clinical outcome buruk. Sedangkan berdasarkan rasio CMax/MIC bakteri E. coli dan K. pneumonia, terdapat 1 pasien dengan estimasi Rasio Cmax/MIC berada diatas rentang nilai optimal yaitu ≥ 8 dengan menunjukkan hasil clinical outcome buruk. Berdasarkan hasil uji fisher menunjukkan bahwa tidak terdapat hubungan signifikan antara kadar gentamisin dalam darah,baik dari rentang terapi (p=0,380), maupun rasio Cmax/MIC pada bakteri E. coli (p=0,556) dan K. pneumonia (p=0,556) terhadap clinical outcome pasien pneumonia anak. Kesimpulan: Tidak terdapat hubungan signifikan antara kadar gentamisin dalam darah,baik dari rentang terapi maupun rasio Cmax/MIC pada bakteri E. coli dan K. pneumonia terhadap clinical outcome pasien pneumonia anak. Kata Kunci: Gentamisin, Estimasi kadar, Clinical Outcome |
| Abtrak (Bhs. Inggris) | Background: Gentamicin is one of the empirical antibiotics used as first-line therapy for severe pneumonia in children. Gentamicin is an antibiotic with a narrow therapeutic index if a small change in drug levels can cause unwanted side effects or can cause toxic effects. The study aims to determine the relationship between gentamicin levels and clinical outcomes of pediatric pneumonia patient. Methods: This study is an observational study with retrospective data collection. Data collection was carried out on the medical records of inpatient pneumonia pediatric patients for the January-December 2020 period at the Margono Soekarjo Hospital, Purwokerto. The research data were analyzed univariately by calculating the pharmacokinetic approach and bivariate with the fisher test to determine the relationship between estimated levels of gentamicin related to therapeutic range and the ratio of CMax/MIC to patient clinical outcomes. Results: A total of 33 patients were included in the inclusion criteria. There were 31 patients with level estimation results within the therapeutic range where 7 patients showed good clinical outcomes and 24 patients with poor clinical outcomes. Meanwhile, based on the CMax/MIC ratio of E. coli and K. pneumoniae bacteria, there is 1 patient with the estimated Cmax/MIC ratio above the range of value optimal, which is 8 by showing poor clinical outcome. Based on the results of fisher tests showed that there was no significant relationship between gentamicin levels in the blood, both from the therapeutic range (p = 0.380) and the Cmax/MIC ratio in E. coli (p = 0.556) and K. pneumoniae (p = 0.556) on the clinical outcome of pediatric pneumonia patients. Conclusion: There was no significant relationship between gentamicin levels in the blood, both from the therapeutic range and the Cmax/MIC ratio in E. coli and K. pneumoniae on the clinical outcome of pediatric pneumonia patients. Keywords: Gentamicin, Estimation of levels, Clinical Outcome |
| Kata kunci | Gentamisin, Estimation of levels, Clinical Outcome |
| Pembimbing 1 | apt. Dewi Latifatul Ilma, M. Clin. Pharm |
| Pembimbing 2 | apt. Masita Wulandari S, M. Sc |
| Pembimbing 3 | |
| Tahun | 2022 |
| Jumlah Halaman | 62 |
| Tgl. Entri | 2022-08-16 11:56:45.681975 |