Artikel Ilmiah : I1B018063 a.n. SEPTI WINDARI
| NIM | I1B018063 |
|---|---|
| Namamhs | SEPTI WINDARI |
| Judul Artikel | Pengaruh Kombinasi Daun Ciplukan (Physalis angulata L.) dan Daun Salam (Syzygium polyanthum) terhadap Kadar Kolesterol Total Tikus Putih Hiperkolesterolemia |
| Abstrak (Bhs. Indonesia) | Latar Belakang : Hiperkolesterolemia merupakan faktor risiko penyakit kardiovaskular. Pada penelitian sebelumnya, daun ciplukan dan daun salam terbukti dapat menurunkan kadar kolesterol total karena mengandung flavonoid, namun kombinasi keduanya belum diteliti. Kombinasi keduanya diharapkan dapat mengoptimalkan penurunan. Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya pengaruh pemberian kombinasi rebusan daun ciplukan dan daun salam untuk tikus putih hiperkolesterolemia. Metode : Penelitian ini menggunakan true eksperiment dengan pendekatan pre-test post-test control group design terhadap tikus wistar jantan yang diinduksi diet tinggi lemak. Sampel sebanyak 36 ekor tikus dibagi menjadi 6 kelompok yaitu kelompok A = kontrol sehat, B = kontrol negatif, C = kombinasi daun ciplukan : daun salam (160 : 720) mg/200 grBB, D = kombinasi daun ciplukan : daun salam (160: 1.440 ) mg/200 gBB, E = kombinasi daun ciplukan : daun salam (320: 720) mg/200 gBB dan F = simvastatin 0,18 mg/200 gBB selama 14 hari. Data yang diperoleh diolah menggunakan software SPSS melalui uji One Way ANOVA pada taraf signifikansi 5% dilanjutkan dengan uji Pos Hoc Duncan. Hasil : Rata-rata penurunan kolesterol total post test pada kelompok C = 68 mg/dl, kelompok D = 26,25 mg/dl, kelompok E = 44,75 dan kelompok F = 55 mg/dl. Ada perbedaan yang signifikan antara kelompok C dan F terhadap kelompok B (p < 0,05) pada uji Post Hoc Duncan. Kesimpulan : Kombinasi rebusan daun ciplukan dan daun salam berpengaruh terhadap kadar kolesterol total pada tikus putih hiperkolesterolemia dengan dosis yang paling efektif adalah dosis kombinasi daun ciplukan dan daun salam (160 : 720) mg/200 gBB. Kata kunci : Hiperkolesterolemia, Kolesterol Total, Kombinasi, Daun Ciplukan, Salam Daun, Simvastatin. |
| Abtrak (Bhs. Inggris) | Background : Hypercholesterolemia is a risk factor for cardiovascular disease. In previous studies, ciplukan leaves and salam leaves have been shown to reduce total cholesterol levels because they contain flavonoids, but the combination of the two has not been studied. The combination of the two is expected to optimize the reduction. The purpose of this study was to determine whether there was an effect of giving a combination of boiled ciplukan leaves and salam leaves to hypercholesterolemic white rats. Methods : This study used a true experiment with a pre-test post-test control group design approach on male Wistar rats induced by high fat diet. A sample of 36 rats was divided into 6 groups, namely group A = healthy control, B = negative control, C = combination of ciplukan leaves: salam leaves (160: 720) mg/200 grBB, D = combination of ciplukan leaves: salam leaves (160: 1,440 ) mg/200 gBW, E = combination of ciplukan leaves: salam leaves (320: 720) mg/200 gBW and F = simvastatin 0.18 mg/200 gBW for 14 days. The data obtained were processed using SPSS software through the One Way ANOVA test at a significance level of 5% followed by the Pos Hoc Duncan test. Results : The average post-test total cholesterol decreased in group C = 68 mg/dl, group D = 26.25 mg/dl, group E = 44.75 and group F = 55 mg/dl. There was a significant difference between groups C and F against group B (p < 0.05) in Duncan's Post Hoc test. Conclusion : Combination of decoction of ciplukan leaves and salam leaves has an effect on total cholesterol levels in hypercholesterolemic white rats with the most effective dose being the combined dose of ciplukan leaves and salam leaves (160: 720) mg/200 gBB. Keywords : Hypercholesterolemia, Total Cholesterol, Combination, Ciplukan Leaf, Salam Leaf, Simvastatin. |
| Kata kunci | Hiperkolesterolemia, Kolesterol Total, Kombinasi, Daun Ciplukan, Salam Daun, Simvastatin. |
| Pembimbing 1 | Prof. Dr. Saryono, S.Kep., M.Kes |
| Pembimbing 2 | Dr. Hernayanti, M.Si |
| Pembimbing 3 | |
| Tahun | 2022 |
| Jumlah Halaman | 10 |
| Tgl. Entri | 2022-02-25 15:55:39.365395 |