Artikel Ilmiah : G1A018060 a.n. TYASTI FAJRI MIFTAHUL JANNAH
| NIM | G1A018060 |
|---|---|
| Namamhs | TYASTI FAJRI MIFTAHUL JANNAH |
| Judul Artikel | PENGARUH PEMBERIAN SARI MARKISA UNGU (Passiflora edulis var edulis) TERHADAP KADAR TOTAL PROTEIN STUDI UJI TOKSISITAS SUBKRONIS PADA TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR |
| Abstrak (Bhs. Indonesia) | Latar Belakang: Markisa ungu merupakan buah kaya akan antioksidan. Antioksidan berlebih dapat memengaruhi fungsi hepar. Fungsi hepar berkaitan dengan sintesis total protein. Tujuan: Mengetahui pengaruh pemberian sari markisa ungu (Passiflora edulis var edulis) dalam jangka waktu subkronis (28 hari) per oral terhadap kadar total protein pada hewan uji tikus (Rattus norvegicus) galur Wistar. Metode: Penelitian eksperimental dengan post-test only with control group design. 50 ekor tikus dibagi ke dalam 5 kelompok secara acak. Kelompok K I: kontrol normal, K II: perlakuan sari markisa ungu berdosis 4,2 mL/200 g BB/hari , K III: perlakuan sari markisa ungu berdosis 8,4 mL/200 g BB/hari, K IV: perlakuan sari markisa ungu berdosis 12,6 mL/200 g BB/hari, K V: perlakuan sari markisa ungu berdosis 16,8 mL/200 g BB/hari. Kadar total protein diperiksa menggunakan metode Biuret. Data dianalisis menggunakan uji Kruskal-Wallis. Hasil: Rerata kadar total protein pada K I, K II, K III, K IV, dan K V berturut-turut adalah 6,31 g/dL, 6,32 g/dL, 6,26 g/dL, 6,53 g/dL, dan 6,5 g/dL. Uji Kruskal-Wallis bernilai p=0,57 (p>0,05). Kesimpulan: Pemberian sari markisa ungu (Passiflora edulis var edulis) dalam jangka waktu subkronis (28 hari) per oral tidak berpengaruh terhadap kadar total protein pada hewan uji tikus (Rattus norvegicus) galur Wistar. |
| Abtrak (Bhs. Inggris) | Background: Purple passion fruit was rich in antioxidants. Excessive amount of antioxidants could affect liver function. The liver function was associated with synthesis of protein total. Aim: To understand the effect of 28 days of oral administration of purple passion fruit juice (Passiflora edulis var edulis) on the level of protein total of white rat (Rattus norvegicus) Wistar in a sub-chronic toxicity test. Methods: Experimental studied with post-test only control group design. 50 rats was randomly divided into 5 groups. Group K I: normal control, K II: treated with purple passion fruit juice at 4.2 mL/200 g BB/day dose, K III: treated with purple passion fruit juice at 8.4 mL/200 g BB/day dose, K IV: treated with purple passion fruit juice at 12.6 mL/200 g BB/day dose, K V: treated with purple passion fruit juice at 16.8 mL/200 g BB/day dose. The protein total level checked by Biuret’s method. Data analyzed by Kruskal-Wallis’s test. Results: The mean level of protein total in group K I, K II, K III, K IV, and K V are 6.31 g/dL, 6.32 g/dL, 6.26 g/dL, 6.53 g/dL, 6.5 g/dL. The Kruskal-Wallis’s test shows p value=0.57 (p>0.05). Conclusion: The administration of purple passion fruit juice does not significantly affect the protein total level of white rat in sub-chronic toxicity test. |
| Kata kunci | Hepar, Sari Markisa Ungu, Total Protein, Uji Toksisitas Subkronis, Wistar. |
| Pembimbing 1 | dr. Alfi Muntafiah, M.Sc. |
| Pembimbing 2 | Nor Sri Inayati, S.Si., M. Biotech. |
| Pembimbing 3 | |
| Tahun | 2022 |
| Jumlah Halaman | 11 |
| Tgl. Entri | 2022-01-24 20:05:48.448597 |