Artikel Ilmiah : G1A018008 a.n. NINE LOISYE PAYOSA SEMBIRING
| NIM | G1A018008 |
|---|---|
| Namamhs | NINE LOISYE PAYOSA SEMBIRING |
| Judul Artikel | Efek Pemberian Teh Kecombrang (Etlingera Elatior) Terhadap Kadar TNF-α Tikus Putih (Rattus Norvegicus) Yang Diinduksi Aspirin |
| Abstrak (Bhs. Indonesia) | Latar Belakang — Induksi aspirin dapat menimbulkan reaksi inflamasi seperti gastritis dan ulkus. Senyawa flavonoid, tanin, saponin pada kecombrang memiliki efek antiinflamasi. Senyawa-senyawa tersebut berpotensi untuk menurunkan kadar TNF-α tikus putih. Tujuan — Mengetahui efek teh kecombrang terhadap kadar TNF-α tikus putih yang diinduksi aspirin. Desain Penelitian — Penelitian ini menggunakan metode true experimental dengan desain post test only with control group. Jumlah sampel yang digunakan pada penelitian ini adalah 45 ekor tikus putih jantan galur Wistar yang dibagi kedalam 15 kelompok, yaitu: Kelompok KST1 (positif), KNT1 (negatif). P1T1: aspirin 10 hari teh 1,5 g/200gBB 7 hari, P2T1: aspirin 10 hari, teh 3 g/200gBB 7 hari, P3T1: aspirin 10 hari, teh 6 g/200gBB, 7 hari. KST2 (positif), KNT2 (negatif). P1T2: aspirin 10 hari, teh 1,5 g/200gBB 14 hari, P2T2: aspirin 10 hari, teh 3 g/200gBB 14 hari, P3T2: aspirin 10 hari teh 6 g/200gBB 14 hari. KST3 (positif), KNT3 (negatif). P1T3: aspirin 10 hari, teh 1,5 g/200gBB 28 hari, P2T3: aspirin 10 hari, teh 3 g/200gBB 28 hari, P3T3: aspirin 10 hari, teh 6 g/200gBB 28 hari. Analisis data mengggunakan uji Kruskal-wallis dan Mann-Whitney. Hasil —Nilai rerata TNF-α terendah terdapat pada kelompok KST1, diikuti KNT1, P1T1, KST2, P3T1, P2T1, P1T2, P2T2, P3T2, P2T3, KST3, P3T3, P1T3, dan KNT3 dengan hasil uji statistic (p=0.000) diantara semua kelompok dan terdapat perbedaan bermakna antar tiap kelompok. Kesimpulan — Teh kecombrang dapat menurunkan kadar TNF-α dengan dosis efektif 1,5 g/200gBB tikus. |
| Abtrak (Bhs. Inggris) | Background — Aspirin induction can cause inflammatory reactions such as gastritis and ulcers. Flavonoid compounds, tannins, saponins in kecombrang have anti-inflammatory effects. These compounds have the potential to reduce TNF-α levels in white rats.. Objective — To determine the effect of kecombrang tea on TNF-α levels of aspirin-induced white rats. Design — This study used a true experimental method with a post test only design with a control group. The samples used in this study were 45 male white rats of wistar strain and divided into 15 groups: KST1 (positive), KNT1 (negative). P1T1: aspirin 10 days, tea 1.5 g/200gBB 7 days, P2T1: aspirin 10 days, tea 3 g/200gBB 7 days, P3T1: aspirin 10 days, tea 6 g/200gBB, 7 days. KST2 (positive), KNT2 (negative). P1T2: aspirin 10 days, tea 1.5 g/200gBB 14 days, P2T2: aspirin 10 days, tea 3 g/200gBB 14 days, P3T2: aspirin 10 days tea 6 g/200gBB 14 days. KST3 (positive), KNT3 (negative). P1T3: aspirin 10 days, tea 1.5 g/200gBW 28 days, P2T3: aspirin 10 days, tea 3g/200gBB 28 days, P3T3: aspirin 10 days, tea 6g/200gBW 28 days. Data analysis using Kruskal-Wallis and Mann-Whitney test. Results —The lowest mean TNF-α value was in the KST1, followed by KNT1, P1T1, KST2, P3T1, P2T1, P1T2, P2T2, P3T2, P2T3, KST3, P3T3, P1T3, and KNT3 with statistical test results (p=0.000) between all groups and there was a significant difference between each group. Conclusion — Kecombrang tea can reduce TNF-α levels with an effective dose of 1.5 g/200gBW rats. |
| Kata kunci | Aspirin, TNF-α, Teh Kecombrang |
| Pembimbing 1 | Dr. dr. Eman Sutrisna, M.Kes |
| Pembimbing 2 | Dr. Hernayanti, M.Si |
| Pembimbing 3 | |
| Tahun | 2022 |
| Jumlah Halaman | 11 |
| Tgl. Entri | 2022-01-16 15:46:40.015754 |