Artikel Ilmiah : I1C016015 a.n. INDRIANA JULIAWATI
| NIM | I1C016015 |
|---|---|
| Namamhs | INDRIANA JULIAWATI |
| Judul Artikel | FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI GEL HAND SANITIZER MINYAK ATSIRI KAYU MANIS (Cinnamomum burmanni) TERHADAP Staphylococcus aureus |
| Abstrak (Bhs. Indonesia) | Penyakit diare merupakan penyakit endemis yang ada di Indonesia. Staphylococcus aureus menghasilkan enterotoksin yang merupakan penyebab utama keracunan makanan yang disertai diare. Hand sanitizer dapat digunakan sebagai alternatif sabun dan air untuk mencuci tangan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi minyak atsiri kayu manis terhadap sifat fisik dan stabilitas fisik sediaan gel hand sanitizer dan mengetahui aktivitas antibakteri sediaan gel hand sanitizer minyak atsiri kayu manis terhadap Staphylococcus aureus. Sediaan gel hand sanitizer dibuat dengan variasi konsentrasi minyak atsiri kayu manis yaitu 0,1%, 0,2% dan 0,5%. Hasil uji sifat fisik dan stabilitas fisik dilakukan secara deskriptif dan dianalisis dengan menggunakan uji one way ANOVA dengan taraf kepercayaan 95% dan dilanjutkan dengan uji Least Significant Differences (LSD). Hasil uji aktivitas antibakteri menggunakan metode difusi sumuran dianalisis dibandingkan terhadap kontrol negatif dan kontrol positif. Peningkatan variasi konsentrasi minyak atsiri kayu manis meningkatkan nilai viskositas dan daya lekat, namun menurunkan nilai daya sebar gel hand sanitizer minyak atsiri kayu manis. Semua formula sediaan gel hand sanitizer minyak atsiri kayu manis memenuhi kriteria yang baik pada sifat fisik dan stabilitas fisik tetapi tidak stabil pada parameter viskositas. Formula sediaan gel hand sanitizer minyak atsiri kayu manis pada konsentrasi 0,1%, 0,2%, dan 0,5% memiliki aktivitas antibakteri terhadap S. aureus. |
| Abtrak (Bhs. Inggris) | Diarrhea is an endemic disease in Indonesia. Staphylococcus aureus produce enterotoxin which is the main cause of food poisoning accompanied by diarrhea. Hand sanitizer can be used as an alternative to soap and water for washing hands. This study aims to determine the effect of variations in the concentration of cinnamon essential oil on the physical properties and physical stability of hand sanitizer gel preparations and to determine the antibacterial activity of cinnamon essential oil hand sanitizer gel preparations against Staphylococcus aureus. Hand sanitizer gel preparation were made with variations in the concentration of cinnamon essential oil, namely 0.1%, 0.2% and 0.5%. The results of the physical properties and physical stability tests were carried out descriptively and analyzed using the one way ANOVA test with a 95% confidence level and continued with the Least Significant Differences (LSD) test. The results of the antibacterial activity test using the well diffusion method were analyzed compared to the negative control and positive control. Increasing variations in the concentration of cinnamon essential oil increased the value of viscosity and adhesion, but decreased the dispersion value of the cinnamon essential oil hand sanitizer gel. All of the hand sanitizer gel formulations of cinnamon essential oil met the criteria for good physical properties and physical stability but were not stable on viscosity parameters. Cinnamon essential oil hand sanitizer gel formulations at concentration of 0.1%, 0.2%, and 0.5% had antibacterial against S. aureus. |
| Kata kunci | Cinnamomum burmanni (Ness ex BI. Cortex), Karbopol 940, Gel Hand Sanitizer, Antibakteri, S. aureus |
| Pembimbing 1 | Drs. Sunarto MS, M.P |
| Pembimbing 2 | apt. Beti Pudyastuti, S.Farm., M.Sc |
| Pembimbing 3 | |
| Tahun | 2021 |
| Jumlah Halaman | 10 |
| Tgl. Entri | 2021-11-11 21:11:02.367517 |