Artikel Ilmiah : G1A016040 a.n. MUHAMMAD RIDWANSYAH
| NIM | G1A016040 |
|---|---|
| Namamhs | MUHAMMAD RIDWANSYAH |
| Judul Artikel | HUBUNGAN KADAR TRANSAMINASE DAN ALBUMIN SERUM DENGAN KADAR CARCINOEMBRYONIC ANTIGEN(CEA) PADA PASIEN KANKER KOLOREKTAL DI RSUD PROF. DR. MARGONO SOEKARJO TAHUN 2014-2020 |
| Abstrak (Bhs. Indonesia) | Latar Belakang : Kanker kolorektal (KKR) merupakan keganasan paling umum ke-3 di dunia dan jenis kanker paling mematikan kedua di negara maju. Carcinoembryonic antigen (CEA) telah digunakan sebagai serum marker/penanda diagnosis dan prognosis kanker kolorektal (KKR) selama beberapa tahun, dan signifikansi serta kegunaannya dalam aplikasi klinis telah dilaporkan dalam banyak penelitian, Kadar CEA serum pre-operasi < 5µg/L dapat digunakan sebagai prediktor kesintasan pasien seperti 5-year survival rate dan tumor-specific survival. Akurasi diagnostik CEA masih tergolong rendah. CEA relatif lebih rendah jika dibandingkan dengan kandidat-kandidat marker KKR yang lain, seperti Macrophage inhibitory cytokine-1 / MIC-1 dan exosomal copine III / CPNE3 dalam memprediksi KKR. Rendahnya akurasi ini dapat dipengaruhi oleh variabilitas hasil pengukuran CEA. Untuk meningkatkan sensitifitas CEA dalam memprediksi KKR, diperlukan analisis lebih jauh terhadap faktor-faktor yang mempengaruhi kadar CEA seperti stadium tumor, kelas tumor, lokasi tumor, aktivitas merokok, obstruksi usus, dan status fungsi hati Tujuan : Mengetahui hubungan kadar CEA pasien dengan penurunan fungsi hati pada pasien kanker kolorektal di RSUD Prof. Dr. Margono Soekarjo. Metode : Rancangan penelitian yang akan digunakan adalah penelitian analitik observasional dengan pendekatan secara cross sectional, pengukuran variabel dilakukan satu kali pada satu saat. Penelitian dilakukan dengan mengumpulkan data sekunder berupa rekam medis. Teknik pengambilan sampel dengan menggunakan teknik total sampling. Hasil : Variabel SGOT dan albumin memiliki korelasi yang signifikan terhadap kadar CEA serum. Kadar SGOT memiliki korelasi positif terhadap kadar CEA (p=0,003; r=0,432) sedangkan kadar albumin serum memiliki korelasi negatif terhadap kadar CEA (p=0,04; r=-0,308). Kesimpulan : Analisis korelasi menunjukkan kadar enzim SGOT berkorelasi positif terhadap kadar CEA serum, sedangkan kadar albumin serum berkorelasi negatif dengan kadar CEA serum pada pasien kanker kolorektal. |
| Abtrak (Bhs. Inggris) | Background: Colorectal cancer is the 3rd most common malignancy in the world and the second most deadly type of cancer in developed countries. Carcinoembryonic antigen (CEA) has been used as a serum marker / marker for the diagnosis and prognosis of colorectal cancer (KKR) for several years, and its significance and use in clinical applications has been reported in many studies, pre-operative serum CEA levels <5µg / L can be used as predictors of patient survival such as 5-year survival rate and tumor-specific survival. The diagnostic accuracy of CEA is still low. CEA is relatively lower when compared to other TRC marker candidates, such as Macrophage inhibitory cytokine-1 / MIC-1 and exosomal copine III / CPNE3 in predicting TRC. This low accuracy can be affected by the variability of the CEA measurement results. To increase the sensitivity of CEA in predicting TRC, further analysis is needed on factors that influence CEA levels such as tumor stage, tumor grade, tumor location, smoking activity, intestinal obstruction, and liver function status. Objective: Knowing the correlation in CEA levels in patients with impaired liver function in colorectal cancer patients at Prof. Dr. Margono Soekarjo Hospital. Method: The research design that will be used is an observational analytic study with a cross sectional approach, the measurement of variables is carried out once at a time. The research was conducted by collecting secondary data in the form of medical records. The sampling technique was using total sampling technique. Results: SGOT and albumin variables have a significant correlation with serum CEA levels. SGOT levels had a positive correlation with CEA levels (p = 0.003; r = 0.432) while serum albumin levels had a negative correlation with CEA levels (p = 0.04; r = -0.308). Conclusion: Correlation analysis shows that SGOT enzyme levels have a positive correlation to serum CEA levels, while serum albumin levels have a negative correlation with serum CEA levels in colorectal cancer patients. |
| Kata kunci | : Kanker Kolorektal, CEA (Carcinoembryonic Antigen), Transaminase, Albumin serum. |
| Pembimbing 1 | I. dr. Kamal Agung W Sp. B-KBD |
| Pembimbing 2 | II. dr. Hidayat Sulistyo ,M.Si,Med,.Sp.PA |
| Pembimbing 3 | |
| Tahun | 2021 |
| Jumlah Halaman | 71 |
| Tgl. Entri | 2021-02-25 10:43:16.440403 |