| NIM | I1C016051 |
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| Namamhs | SABRINA PRAMUDINTA KUSUMANINGRUM |
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| Judul Artikel | REVIEW: AKTIVITAS IMUNOMODULATOR DAN ANTIINFLAMASI DARI SAMBILOTO (Andrographis paniculata (Burm. f.) Nees) DAN ANDROGRAPHOLIDE |
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| Abstrak (Bhs. Indonesia) | Sambiloto (Andrographis paniculata (Burm. f.) Nees) telah terbukti memiliki berbagai aktivitas farmakologi. Penelitian ini bertujuan untuk mengetahui aktivitas imunomodulator dan antiinflamasi pada ekstrak sambiloto dan isolat andrographolide, sehingga berpotensi sebagai obat. Penelitiaan non eksperimental ini menggunakan desain penelitian literatur review terhadap 19 artikel. Pencarian literatur secara elektronik menggunakan PubMed, ScienceDirect, dan Google Scholar. Penentuan literatur berdasarkan kriteria inklusi dan eksklusi. Proses literatur review terdiri dari identifikasi, seleksi, eligibilitas, dan inklusi. Data aktivitas farmakologi sambiloto dianalisis secara deskriptif kualitatif dalam bentuk tabel. Hasil penelitian menunjukkan bahwa ekstrak, fraksi maupun filtrat sambiloto serta senyawa aktif andrographolide dan turunannya terbukti memiliki aktivitas sebagai imunomodulator dan antiinflamasi pada studi in vitro dan in vivo dengan menurunkan sitokin dan kemokin proinflamasi serta meningkatkan aktivitas fagositosis dan sel limfosit T. Inflamasi merupakan respon cepat tubuh ketika terjadi kerusakan, sehingga mengeluarkan sitokin. Sitokin berperan membawa sinyal regulasi imunitas bawaan maupun adaptif untuk melawan patogen. Ekstrak sambiloto (Andrographis paniculata (Burm. f.) Nees) dan isolat andrographolide diketahui dapat menyeimbangkan antara sitokin proinflamasi dan sitokin antiinflamasi, sehingga berperan sebagai imunomodulator dan antiinflamasi. |
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| Abtrak (Bhs. Inggris) | Sambiloto (Andrographis paniculata (Burm. F.) Nees) has been shown to have various pharmacological activities. This study aims to determine the immunomodulatory and anti-inflammatory activity of sambiloto extract and andrographolide isolate, so that they have potential as medicine. This non-experimental study used a literaturestudy design review of 19 articles. Search for literature electronically using PubMed, ScienceDirect, and Google Scholar. Determination of literature based on inclusion and exclusion criteria. The literature review process consists of identification, selection, eligibility, and inclusion. Sambiloto pharmacological activity data were analyzed descriptively qualitatively in tabular form. The results showed that the extract, fraction and filtrate of sambiloto as well as the active compound andrographolide and its derivatives were proven to have immunomodulatory and anti-inflammatory activity in in vitro and in vivo studies by reducing proinflammatory cytokines and chemokines and increasing phagocytosis activity and T lymphocyte cells. Inflammation is the body's quick response to damage, thereby releasing cytokines. Cytokines play a role in carrying signals of innate and adaptive regulation of immunity to fight pathogens. Sambiloto extract (Andrographis paniculata (Burm. F.) Nees) and andrographolide isolate are known to balance pro-inflammatory cytokines and anti-inflammatory cytokines, thus acting as immunomodulators and anti-inflammatory. |
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| Kata kunci | Andrographis paniculata (Burm. f.) Nees, andrographolide, imunomodulator, antiinflamasi |
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| Pembimbing 1 | Dr. apt. Eka Prasasti N.R., M.Sc. |
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| Pembimbing 2 | apt. Rehana, M.Si |
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| Pembimbing 3 | |
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| Tahun | 2021 |
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| Jumlah Halaman | 10 |
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| Tgl. Entri | 2021-01-29 22:08:53.623037 |
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