| NIM | G1B015045 |
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| Namamhs | REYGALIAN NOVALITA PURBANINGTYAS |
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| Judul Artikel | POLA KADAR PROLINE RICH PROTEIN (PRP) PADA SALIVA ANAK DAN REMAJA DOWN SYNDROME RENTANG USIA 8-24 TAHUN |
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| Abstrak (Bhs. Indonesia) | Saliva merupakan cairan yang terdapat dalam rongga mulut. Pada saliva terdapat kandungan protein, salah satunya adalah Proline Rich Protein (PRP). Proline Rich Protein (PRP) mempunyai fungsi salah satunya untuk mencegah terjadinya karies. Pada beberapa penelitian, terdapat perbedaan hasil konsentrasi Proline Rich Protein (PRP) antara individu dengan down syndrome dan non down syndrome. Tujuan penelitian ini adalah untuk mengetahui adanya perbedaan pola kadar Proline Rich Protein (PRP) pada anak dan remaja down syndrome dan non down syndrome berdasarkan masing-masing usia dalam rentang 8-24 tahun. Jenis penelitian ini adalah deskriptif analitik dengan pendekatan cross sectional dan menggunakan 14 individu down syndrome dan 14 individu non down syndrome rentang usia 8-24 tahun yang dibagi kelompok menurut masing-masing usia. Kelompok down syndrome dipilih dengan metode total sampling, sedangkan untuk kelompok non down syndrome dengan metode purposive sampling dengan cara matching berdasarkan usia dan jenis kelamin. Hasil penelitian menunjukkan terdapat perbedaan pola kadar Proline Rich Protein (PRP) antara kelompok down syndrome usia 10 tahun cenderung tinggi dan kemudian berangsur turun hingga usia 16 tahun. Kadar Proline Rich Protein (PRP) kembali naik hingga usia 24 tahun, sedangkan pada kelompok non down syndrome pada usia 10 tahun mempunyai kadar lebih rendah dari down syndrome. Kadar tertinggi pada non down syndrome terdapat pada usia 16 tahun dan kembali menurun hingga usia 24 tahun. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat perbedaan garis pola kadar Proline Rich Protein (PRP) pada anak down syndrome dan non down syndrome berdasarkan masing-masing usia dalam rentang 8-24 tahun, sedangkan hasil uji independen T-test mendapat hasil tidak berbeda signifikan pada kadar Proline Rich Protein (PRP) antara individu down syndrome dan non down syndrome dalam rentang usia 8-24 tahun. |
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| Abtrak (Bhs. Inggris) | Saliva is a liquid that found in the oral cavity. One of content of saliva is Proline Rich Protein (PRP). Proline Rich Protein (PRP) has a function to prevent caries. In some studies, there are differences in the results of Proline Rich Protein (PRP) concentrations between individuals with down’s syndrome and without down’s syndrome. This research aimed to determine the differences in the pattern of salivary Proline Rich Protein (PRP) concentration in children and teenagers with Down’s Syndrome and without Down’s Syndrome based on each age between 8-24 years old. The number of samples study were 14 subject who were divided into the groups of children and teenagers with down's syndrome and without down’s syndrome. The samples of down’s syndrome were selected by the total sampling method, while for the samples of non-down’s syndrome were selected by matching purposive sampling method. The result of this research indicated that Proline Rich Protein (PRP) concentration was higher in the youngest subjects with down’s syndrome (10-years-old) than in the other groups, decreased until 1,2 ng/ml at 16-years-old, but slightly increase at 24-years-old (3,49 ng/ml). The non down’s syndrome group showed the different pattern of proline rich protein. The concentration in subjects without down’s syndrome were increased after 10-years-old and reached the higher concentration in 16-years-old (8,22 ng/ml). The concentration were decreased after 16-years-old in subjects without down’s syndrome and showed the minimum concentration in the 24-years-old. This research had a summary that there were differences in the pattern of salivary Proline Rich Protein (PRP) concentration in subjects with down’s syndrome and without down’s syndrome and result of independent t-test showed that there were no differen in concentration Proline Rich Protein (PRP) between down syndrome and non down syndrome subject. |
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| Kata kunci | down syndrome, saliva, usia, Proline Rich Protein (PRP |
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| Pembimbing 1 | Dr. Dra Hernayanti, M.Si |
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| Pembimbing 2 | drg. Amilia Ramadhani, M.Sc |
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| Pembimbing 3 | |
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| Tahun | 2019 |
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| Jumlah Halaman | 14 |
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| Tgl. Entri | 2019-08-26 19:02:20.618187 |
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