Artikel Ilmiah : G1A015023 a.n. SINDY DEVI PRASTIWI
| NIM | G1A015023 |
|---|---|
| Namamhs | SINDY DEVI PRASTIWI |
| Judul Artikel | EFEK PEMBERIAN EKSTRAK ETANOL SELEDRI (Apium graveolens L.) TERHADAP KADAR KREATININ SERUM TIKUS PUTIH (Sprague dawley) MODEL CHRONIC KIDNEY DISEASE |
| Abstrak (Bhs. Indonesia) | Latar Belakang: Gagal Ginjal Kronik merupakan kerusakan ginjal dan/atau penurunan laju filtrasi glomerulus (LFG) berakibat pada peningkatan kadar kreatinin. Ekstrak etanol seledri (Apium graveolens L.) berfungsi sebagai antioksidan dan antiinflamasi yang berpotensi mencegah kerusakan pada ginjal. Tujuan: Penelitian ini bertujuan untuk mengetahui efek pemberian seledri (Apium graveolens L.) dalam mencegah peningkatan kadar kreatinin tikus putih (Sprague dawley) model CKD. Desain Penelitian: Metode penelitian adalah eksperimental dengan post test only with control group design. Dua puluh lima ekor tikus jantan (2-3 bulan) dibagi dalam 5 kelompok. Kelompok A (larutan aquades) sebagai kontrol sehat, kelompok B (larutan aquades) sebagai kontrol sakit, kelompok C (250 mg/kgBB), kelompok D (500 mg/kgBB), dan kelompok E (1000 mg/kgBB). Pada hari ke 15 setelah pemberian ekstrak, kelompok B, C, D, E dibedah dan dibuat model 5/6 nefrektomi subtotal. Pemberian ekstrak dilanjutkan sampai hari ke 30. Hasil: Rerata kadar kreatinin serum kelompok A=1,32±0,06; B=1,46±0,08; C=1,30±0,06; D=1,38±0,04; E=1,37±0,05. Hasil uji One Way ANOVA rerata kadar kreatinin serum menunjukkan nilai yang signifikan (p<0,05). Uji post hoc LSD rerata kadar kreatinin serum menunjukkan hasil perbedaan rerata yang signifikan antara kelompok A dengan kelompok B, kelompok B dengan C dan kelompok B dengan E (p<0,05). Kesimpulan: Pemberian ekstrak etanol seledri (Apium graveolens L.) dapat mencegah peningkatan kadar kreatinin serum tikus model CKD, dengan dosis 250 mg/kgBB sebagai dosis efektif. |
| Abtrak (Bhs. Inggris) | Background: Chronic Kidney Disease (CKD) is kidney damage and /or a decrease in glomerular filtration rate (GFR) which results in increased creatinine levels. Ethanol extract of celery (Apium graveolens L.) functions were antioxidant and anti-inflammatory which has the potential effect to prevent kidney damage. Objective: The aim of this research was to analyze the effect of celery (Apium graveolens L.) ethanol extract in preventing the increase of creatinine serum level in CKD rats model (Sprague dawley). Design: This was an experimental study with post test only control group design. Twenty five rats male (2-3 months old) were devided into 5 groups. Group A (aquadest) as healthy control, group B (aquadest) as nefrectomy group, group C (250 mg/kgBW of celery extract), group D (500 mg/kgBW of celery extract), and group E (1000 mg/kgBW of celery extract). On the 15th day after giving the extract and CMC, group B, C, D, and E were dissected and made 5/6 subtotal nephrectomy. Then the extract and CMC was continue gived until 30th day. Results: The mean of creatinine level in group A=1.32±0.06; B=1.46±0.08; C=1.30±0.06; D=1.38±0.04; E=1.37±0.05. One Way ANOVA test showed that there was significantly defferences of creatinine serum level between (p <0.05). The post hoc LSD test on creatinine serum level showed significant differences between group A with B and between group B with C and between group B wuth E (p <0.05). Conclusion: The administration of ethanol extract of celery (Apium graveolens L.) can prevent the increase creatinine serum levels in CKD rats model with effective doses 250 mg/kgBB. |
| Kata kunci | Apium graveolens L., Gagal Ginjal Kronik, Kreatinin, Nefrektomi subtotal, Seledri |
| Pembimbing 1 | dr. Afifah, M.Sc |
| Pembimbing 2 | dr. Wiwiek Fatchurohmah, M.Sc |
| Pembimbing 3 | |
| Tahun | 2019 |
| Jumlah Halaman | 12 |
| Tgl. Entri | 2019-07-12 08:57:40.483369 |