Artikel Ilmiah : G1F014021 a.n. DIVA FATHARANI AN UMILLAH
| NIM | G1F014021 |
|---|---|
| Namamhs | DIVA FATHARANI AN UMILLAH |
| Judul Artikel | FORMULASI DAN UJI AKTIVITAS SEDIAAN SABUN GEL MINYAK SERAI WANGI (Citronella Oil) DENGAN BASIS HIDROKSI PROPIL METIL SELULOSA TERHADAP Candida albicans |
| Abstrak (Bhs. Indonesia) | Minyak serai wangi mengandung citronella yang memiliki aktivitas antifungi terhadap C. albicans, sehingga dapat diformulasikan menjadi sediaan sabun gel kewanitaan. Penelitian ini bertujuan untuk mengetahui pengaruh HPMC terhadap sifat fisik dan stabilitas sediaan sabun gel, mendapatkan formula terpilih dan mengetahui aktivitas sabun gel minyak serai wangi terhadap C. albicans. Sabun gel minyak serai wangi dibuat dengan variasi konsentrasi HPMC 1,5%; 1,75%; 2%; dan 2,25%. Hasil uji sifat fisik berupa organoleptis, homogenitas dan uji stabilitas fisik dianalasis secara dekskriptif, sedangkan pH, kemampuan dan stabilitas busa, viskositas, dan persentase zat padat dianalisis menggunakan ANOVA satu arah. Formula terpilih di uji aktivitas antifungi menggunakan metode difusi sumuran. Hasil penelitian menunjukkan bahwa peningkatan variasi konsentrasi HPMC dapat meningkatkan viskositas sabun gel secara signifikan (p value=0,000). Formula terpilih adalah FI dengan konsentrasi HPMC 1,5%. Formula terpilih memiliki sifat fisik pH 4,6±0,05; viskositas 4137±305 cps; kemampuan dan stabilitas busa 30±3 mL; dan persentase zat padat 5,2±0,2 %. Diameter zona hambat formula terpilih FI terhadap C. albicans adalah 21,67 mm. |
| Abtrak (Bhs. Inggris) | Citronella essential oil contains citronella which has antifungal activity that can be formulated into gel soap againts C. albicans. The purpose of this study was to determine the effect of HPMC on the physical properties and stability of gel soap, to obtain the selected formula, and to determine the activity of citronella oil gel soap on C. albicans. The citronella oil gel soap was made with variations of HPMC concentrations of 1,5%; 1,75%; 2%; and 2,25%. The physical properties include organoleptic, homogenity and physic stability test were analyzed descriptively, while pH, foam ability and stability, viscosity, dan percentage of solids were analyzed using oneway ANOVA. Selected formula was tested for antifungal activity againts Candida albicans used well diffusion method. The research result showed that variation increase of HPMC concentration significantly increased the viscosity of gel soap (p value = 0,000). The selected formula is FI with 1,5% HPMC concentration. Selected formula had physical properties of pH 4,6±0,05; viscosity 4137±305 cps; foam ability and stability 30±3 mL; and percentage of solid 5,2±0,2 %. The diameter inhibitiory zone of the selected formula FI to C. albicans was 21,67 mm. |
| Kata kunci | Minyak Serai Wangi, Sabun Gel, HPMC, Candida albicans |
| Pembimbing 1 | Nuryanti, M.Sc., Apt |
| Pembimbing 2 | Dr. Warsinah, M.Si., Apt |
| Pembimbing 3 | |
| Tahun | 2018 |
| Jumlah Halaman | 6 |
| Tgl. Entri | 2018-06-07 20:52:31.803028 |