Artikel Ilmiah : G1A014078 a.n. SAFIRA AULIA RAHMA
| NIM | G1A014078 |
|---|---|
| Namamhs | SAFIRA AULIA RAHMA |
| Judul Artikel | PERBEDAAN KADAR TESTOSTERON SERUM TIKUS PUTIH (Rattus norvegicus) JANTAN PASCA INDUKSI BERBAGAI MODEL STRES SLEEP DEPRIVATION |
| Abstrak (Bhs. Indonesia) | Latar belakang : Paradoxical sleep deprivation (PSD) dan total sleep deprivation (TSD) dapat menyebabkan gangguan aksis HPA, aksis HPG, dan peningkatan stres oksidatif yang berhubungan dengan masalah infertilitas pria. Sleep recovery (SR) dapat menginduksi pengeluaran hormon melatonin sebagai antioksidan untuk memperbaiki fungsi reproduksi pria. Tujuan : Mengetahui perbedaan kadar testosteron serum pada tikus putih (Rattus norvegicus) jantan pasca induksi berbagai model stres sleep deprivation Metode : Penelitian ini merupakan penelitian eksperimental dengan desain posttest only with control group. Tiga puluh ekor tikus putih dibagi secara acak menjadi 5 kelompok yaitu A (kontrol sehat), B (PSD 20 jam/hari selama 5 hari), C (TSD 24jam/hari selama 5 hari), D (PSD 20 jam/hari selama 5 hari pertama dilanjutkan dengan sleep recovery selama 5 hari berikutnya), dan E (TSD selama 24 jam/hari selama 5 hari pertama dilanjutkan dengan sleep recovery selama 5 hari berikutnya). Hasil : Rerata kadar Testosteron tertinggi terdapat pada kelompok B (19,79±9,22 ng/ml), diikuti kelompok D (14,78±9,78 ng/ml), kelompok A (13,68±6,02 ng/ml), kelompok E (10,48±4,83 ng/ml), dan terendah kelompok C (10,30±5,65 ng/ml). Uji One Way ANOVA menunjukkan tidak terdapat perbedaan signifikan (p>0,05) rerata kadar tetsosteron pada semua kelompok penelitian. Kesimpulan : Tidak terdapat perbedaan signifikan rerata kadar Testosteron Serum pada tikus putih (Rattus norvegicus) jantan pasca induksi berbagai model stres sleep deprivation. Kata kunci : Paradoxical Sleep Deprivation (PSD), Total Sleep Deprivation (TSD), Sleep Recovery, Testosteron Serum (T) |
| Abtrak (Bhs. Inggris) | THE DIFFERENCE OF TESTOSTERON SERUM LEVEL IN MALE ALBINO RATS (Rattus norvegicus) AFTER INDUCTION VARIOUS MODELS OF SLEEP DEPRIVATION STRESS Safira Aulia1, Fitranto Arjadi2, Vitasari Indriani3 Medical Faculty, Jenderal Soedirman University, Purwokerto, Jawa Tengah, Indonesia E-mail: safiraku8@gmail.com ABSTRACT Background : Sleep Deprivation can cause disrupt of HPA axis, HPG axis, and increased oxidative stress which related with male infertility. Sleep recovery (SR) can induce secretion of melatonin as an antioxidant to improve male reproduction function. Objective : To know the difference of Testosteron Serum level in male albino rats (Rattus norvegicus) after induction various models of sleep deprivation stress. Method: This research was an experimental research with posttest only and control group design. Thirty male albino rats were distributed into 5 groups, A (health control), B (PSD 20 hours/day for 5 days), C (TSD 24 hours/day for 5 days), D (PSD 20 hours/day for the first 5 days then continue with sleep recovery for the next 5 days), and E (TSD 24 hours/day for the first 5 days then continue with sleep recovery for the next 5 days). Result: The highest mean of Testosteron found in group B (19,79±9,22 ng/ml), followed by group D (14,78±9,78 ng/ml), group A (13,68±6,02 ng/ml), group E (10,48±4,83 ng/ml), while the lowest mean found in group C (10,30±5,65 ng/ml). One Way ANOVA test showed no significant difference (p> 0,05) of Testosteron mean level in all study groups. Conclusion : There was no significant difference of Testosteron Serum mean level in male albino rats (Rattus norvegicus) after the induction various models of sleep deprivation stress. Keyword : Paradoxical Sleep Deprivation (PSD), Total Sleep Deprivation (TSD), Sleep Recovery, Testosteron Serum (T) |
| Kata kunci | Paradoxical Sleep Deprivation (PSD), Total Sleep Deprivation (TSD), Sleep Recovery, Testosteron Serum (T) |
| Pembimbing 1 | Dr. dr. Fitranto Arjadi, M. Kes |
| Pembimbing 2 | dr.Vitasari Indriani, M.M, Msi. Med, Sp. PK |
| Pembimbing 3 | |
| Tahun | 2018 |
| Jumlah Halaman | 14 |
| Tgl. Entri | 2018-02-01 09:11:28.319468 |