| NIM | G1A013072 |
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| Namamhs | MUHAMMAD MUKTI NURRIYADI |
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| Judul Artikel | PERBANDINGAN EFEKTIVITAS SARI BUAH MARKISA UNGU (Passiflora edulis var edulis) DAN SIMVASTATIN TERHADAP GAMBARAN PERLEMAKAN HEPAR PADA TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR WISTAR MODEL HIPERKOLESTEROLEMIA |
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| Abstrak (Bhs. Indonesia) | Latar Belakang: Peningkatan kadar asam lemak pada keadaan hiperkolesterolemia memicu penumpukan lemak di hepar yang menyebabkan perlemakan hepar. Simvastatin merupakan obat standar hiperkolesterolemia yang belum banyak diketahui pengaruhnya terhadap perlemakan hepar. Buah markisa ungu memiliki kandungan aktif antioksidan flavonoid, dan vitamin C yang memiliki potensi memperbaiki perlemakan hepar. Penelitian ini bertujuan untuk mengetahui perbandingan efektivitas sari buah markisa ungu (Passiflora edulis var edulis) dan simvastatin terhadap gambaran perlemakan hepar tikus (Rattus norvegicus) jantan galur Wistar model hiperkolesterolemia. Metode: Desain penelitian ini menggunakan post test only with control group design dengan 24 ekor tikus dibagi menjadi empat kelompok (K); K1 (kontrol sehat n=6), K2 (kontrol negatif n=6), K3 (sari markisa ungu 4,2 mL/200gram BB/hari n=6), dan K4 (simvastatin 0,18 mg/200gram BB/hari n=6). Induksi hiperkolesterolemia pada K2, K3, dan K4 menggunakan minyak babi 3 mL/200gram BB dua kali dalam sehari dan Propiltiourasil (PTU) 12,5 mg/hari terbagi dalam dua dosis selama 14 hari. Hasil: Perlemakan hepar dihitung menggunakan NAFLD Activity Score (NAS). Rerata skor NAS pada K1: 1,49 ± 0,40, K2: 4,16 ± 0,75, K3: 1,16 ± 0,75, K4: 1,83 ± 2,22. Uji Kruskall Wallis skor perlemakan hepar mendapatkan hasil signifikan (p<0,05), selanjutnya post hoc Mann Whitney menunjukkan perbedaan signifikan antara kelompok 2 terhadap kelompok 1 dan 3, tidak terdapat perbedaan signifikan antara kelompok 2 terhadap kelompok 4 dan kelompok 3 terhadap kelompok 4. Kesimpulan: Kesimpulan penelitian ini adalah sari markisa ungu memiliki efektivitas yang lebih baik dalam memperbaiki gambaran perlemakan hepar tikus putih model hiperkolesterolemia dibandingkan simvastatin. |
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| Abtrak (Bhs. Inggris) | Background: Increased level of fatty acid in hypercholesterolemic state triggers the accumulation of fat in liver that causes fatty liver disease. Simvastatin is a standard drug for hypercholesterolemia and its effect on fatty liver is not yet known thoroughly. Purple passion fruit contains active antioxidant flavonoid and vitamin C that has the potential to improve fatty liver disease. The purpose of this study was to compare the effectiveness of purple passion fruit juice (Passiflora edulis var edulis) and simvastatin on the images of fatty liver in male Wistar rats (Rattus norvegicus) of hypercholesterolemic model. Method: This study design used the post-test only with control group design with twenty four rats divided into four groups: K1(healthy controls n=6), K2(negative control n=6), K3(purple passion fruit juice 4.2 mL/200gram weight/day n=6), and K4(simvastatin 0.18 mg/200gram weight/day n=6). Animals on K2, K3, and K4 were induced by hypercholesterolemia using lard 3 mL/200gram weight twice a day and Propylthiouracil (PTU) 12.5 mg/day in two divided doses for 14 days. Results: Fatty liver was calculated using the NAFLD Activity Score (NAS). The Mean score of NAS in K1: 1,49 ± 0,40, K2: 4,16 ± 0,75, K3: 1,16 ± 0,75, K4: 1,83 ± 2,22.. Kruskal Wallis test showed significant differences (p < 0,05), and the following test post hoc Mann Whitney showed significant differences between group 2 to group 1 and group 3. However there were no significant differences between group 2 to group 4 and group 3 to group 4. Conclusion: The results of this study concluded that the purple passion fruit juice is more effective in improving the images of fatty liver of the hypercholesterolemic rats model compared to simvastatin. |
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| Kata kunci | Sari buah markisa ungu, simvastatin, Perlemakan Hepar, NAFLD Activity Score, Hiperkolesterolemia |
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| Pembimbing 1 | dr. Ika Murti Harini, M.Sc |
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| Pembimbing 2 | dr. Alfi Muntafiah, M.Sc |
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| Pembimbing 3 | |
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| Tahun | 2017 |
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| Jumlah Halaman | 11 |
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| Tgl. Entri | 2017-03-30 12:59:00.578599 |
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