| NIM | G1A013069 |
|---|
| Namamhs | SOFYAN HARDI |
|---|
| Judul Artikel | PERBANDINGAN EFEKTIVITAS SARI MARKISA UNGU (Passiflora edulis var edulis) DAN SIMVASTATIN TERHADAP KADAR MALONDIALDEHID TIKUS PUTIH (Rattus norvegicus) MODEL HIPERKOLESTEROLEMIA |
|---|
| Abstrak (Bhs. Indonesia) | Hiperkolesterolemia menyebabkan peningkatan proses peroksidasi lipid yang ditandai dengan tingginya kadar malondialdehid. Simvastatin sebagai obat standar hiperkolesterolemia dan markisa ungu yang mengandung berbagai macam antioksidan diharapkan mampu menurunkan kadar kolesterol dan malondialdehid. Tujuan penelitian ini untuk mengetahui perbandingan efektivitas sari markisa ungu (Passiflora edulis var edulis) dan simvastatin terhadap kadar malondialdehid tikus putih (Rattus norvegicus) model hiperkolesterolemia. Penelitian ini merupakan eksperimental dengan post test only with control group design. Objek penelitian 32 ekor tikus putih dibagi ke dalam 4 kelompok. Kelompok 1 (kontrol sehat), kelompok 2 (kontrol negatif), kelompok 3 (sari markisa ungu 4,2 mL/200 gBB/hari), kelompok 4 (simvastatin 0,18 mg/200 gBB/hari). Induksi hiperkolesterolemia dilakukan selama 14 hari menggunakan minyak babi dan propiltiourasil (PTU). Pengukuran MDA menggunakan metode TBARS. Uji distribusi data menggunakan Saphiro-Wilk, uji beda menggunakan One Way Anova dan post hoc LSD. Hasil penelitian menunjukkan rerata kadar MDA kelompok 1: 0,61 ± 0,03 µmol/L, kelompok 2: 0,61 ± 0,03 µmol/L, kelompok 3: 0,78 ± 0,07 µmol/L, dan kelompok 4: 1,20 ± 0,08 µmol/L. Uji One Way ANOVA menunjukkan perbedaan signifikan (p=0,00), uji Post Hoc LSD menunjukkan K1 vs K2 p<0,05; K2 vs K3 p<0,05; K2 vs K4 p<0,05; dan K3 vs K4 p<0,05. Penelitian ini menyimpulkan bahwa pemberian sari markisa ungu lebih efektif dalam menurunkan kadar malondialdehid tikus putih (Rattus norvegicus) model hiperkolesterolemia dibandingkan dengan pemberian simvastatin. |
|---|
| Abtrak (Bhs. Inggris) | Hypercholesterolemia led to increased lipid peroxidation process are characterized by high levels of malondialdehyde. Simvastatin as the standard drug hypercholesterolemia and purple passion fruit contains a variety of antioxidants is expected reduce cholesterol levels and malondialdehyde. The purpose of this study to find out the comparative effectiveness of purple passion fruit juice (Passiflora edulis var edulis) and simvastatin on levels of malondialdehyde rat (Rattus norvegicus) model of hypercholesterolemia. This study is experimental with post test only control group design. The object of research 32 rats were divided into 4 groups. Group 1 (healthy controls), group 2 (negative control), Group 3 (purple passion fruit juice 4,2 mL/200 gBW/day), Group 4 (simvastatin 0,18 mg/200 gBW/day). Induction hypercholesterolemia conducted over 14 days using lard and propylthiouracil (PTU). Malondialdehyde content measurement using the TBARS method. Distribution data is tested using the Shapiro-Wilk test, multivariate analysis was tested by using One Way ANOVA and post hoc LSD. The results showed average levels of MDA at group 1: 0.61 ± 0.03 mol / L, group 2: 0.61 ± 0.03 mol / L, group 3: 0.78 ± 0.07 mol / L, and group 4 : 1.20 ± 0.08 mol / L. One Way ANOVA test showed a significant difference (p = 0.00), Post Hoc LSD test showed K1 vs K2 p<0,05; K2 vs K3 p<0,05; K2 vs K4 p<0,05; dan K3 vs K4 p<0,05. The study concluded that purple passion fruit juice is more effective in lowering levels of malondialdehyde white male rats (Rattus norvegicus) model of hypercholesterolemia compared with simvastatin. |
|---|
| Kata kunci | malondialdehid, hiperkolesterolemia, markisa ungu, simvastatin. |
|---|
| Pembimbing 1 | Dr. Dra. Hernayanti, M.Si |
|---|
| Pembimbing 2 | dr. Alfi Muntafiah, M.Sc |
|---|
| Pembimbing 3 | |
|---|
| Tahun | 2017 |
|---|
| Jumlah Halaman | 12 |
|---|
| Tgl. Entri | 2017-02-06 19:47:42.05824 |
|---|