Update Artikelilmiah: 5376

KHAFIZATI AMALINA FITRI ROSADI

NIM

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Abstrak (Bhs. Indonesia)

Latarbelakang. Hiperglikemi diketahui berhubungan langsung dengan komplikasi pada DM Tipe 2. HbA1c dapat mendeteksi hiperglikema kronik, dan HDL-C sebagai lipoprotein anti aterogenik dan inflamasi diduga akan menurun kadarnya jika dalam kondisi hiperglikemi. Rendahnya kadar HDL-C diketahui berhubungan dengan peningkatan keparahan aterosklerosis.
Tujuan. Untuk mengetahui hubungan kadar HbA1c dan HDL-C pasien Prolanis DM Tipe 2 di Banyumas.
Metodologi. Desain penelitian ini adalah analitik observasional dengan pendekatan cross sectional, yang menghubungkan kadar HbA1c dan kadar HDL-C pada 40 pasien DM Tipe 2 di Klinik Dokter Prolanis Banyumas. Pasien yang terdiagnosis DM Tipe 2 dan berusia >20 tahun menjadi responden pada penelitian ini, pasien yang didapati mengalami obesitas sentral, perokok berat, mengonsumsi niasin, hipertiroid, menggunakan estrogen subtitusi, dan menggunakan insulin subtitusi dieksklusi dari penelitian ini. Data primer berupa kadar HbA1c dibaca dengan Fotometer 5010 metode Quantitative Colorimetric, dan kadar HDL-C dibaca dengan Fotometer 5010 metode Enzyme Colorimetric.
Hasil . Dari 40 reponden, didapatkan kadar HbA1c dan HDL-C yang dianalisis hubungan menggunakan uji parametrik Pearson memperoleh nilai p = 0,007 dengan nilai r = -0,418.
Kesimpulan. Kesimpulan dari penelitian ini adalah semakin tinggi kadar HbA1c maka semakin rendah kadar HDL-C pasien prolanis DM Tipe 2 di Banyumas.

Abtrak (Bhs. Inggris)

Background. Hyperglycemia is a condition which is known directly associated with complications. HbA1c can detect chronic hyperglycemia, and HDL-C, anti-atherogenic and inflammation lipoproteins, levels are expected to decrease in the condition of hyperglycemia. Low level of HDL-C is known associated with atherosclerosis.
Objectives. To determine the relationship between HbA1c levels and HDL-C of Type 2 DM prolanis patients
Methods. The study design is observational analytical with cross sectional approach. Patients who are diagnosed Type 2 DM and older than 20 years are include in this study. Patients who are found obese centrally, heavy smokers, consuming niacin, hyperthyroidism, use estrogen substitution, and using insulin substitution were excluded from this study. The primary data of HbA1c levels Photometer 5010 were read with Quantitative Colorimetric method and HDL-C levels were read with Photometer 5010 Enzyme Colorimetric method.
Results. From 40 respondents, showed the result  of  HbA1c and HDL-C level which after that would be analyzed  the relationship using the parametric Pearson correlation test isp-value = 0.007 obtained with r = -0.418.
Conclusions. The conclusion from this study is that increasing level of HbA1c would make the decreasing level of HDL-C in Prolanis Patients with  Type 2 DM in Banyumas.

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