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Abstrak (Bhs. Indonesia)

Ekstrak etanol daun mangga bapang (Mangifera indica ‘Bapang’) diketahui mengandung mangiferin yang mempunyai aktivitas antidiabetes pada pasien diabetes melitus. Penelitian ini bertujuan untuk mendapatkan formula tablet ekstrak etanol daun mangga bapang yang memenuhi syarat sifat fisik tablet dan mengetahui pengaruh variasi penambahan matriks guar gum terhadap sifat mukoadesif tablet.
Tablet dibuat menggunakan metode granulasi basah yang memvariasikan kadar guar gum sebagai matriks bioadesif. Tablet diuji sifat fisiknya dan daya mukoadesifnya diuji secara in vitro menggunakan alat silinder berputar dan diamati selama 8 jam.
Hasil penelitian menunjukkan bahwa tablet ekstrak etanol daun mangga bapang mempunyai karakteristik fisik yang memenuhi syarat sifat fisik tablet. Uji mukoadesif  secara in vitro menunjukkan bahwa semua formula tablet memiliki daya mukoadesif yang bagus. Daya mukoadesif meningkat seiring meningkatnya guar gum. Hasil penelitian menunjukkan formula 4 dengan kadar guar gum paling tinggi memiliki daya mukoadesif yang paling besar yaitu dapat melekat selama 7±1 jam.

Abtrak (Bhs. Inggris)

Ethanolic extract mango’s leaves variety bapang (Mangifera indica ‘Bapang’) known to contains mangiferin which has antidiabetic activity in patients with diabetes mellitus. This study aimed to obtain a formulation of tablets of ethanolic extract mango’s leaves variety bapang are qualified characteristic physical of tablets and know the effect of variations concentration of guar gum on the adhesion of mucoadhesive.
Tablets were made using wet granulation method that varying levels of guar gum as a bioadhesive matrix. Tablets were tested physical characteristics and mucoadhesive strength were tested in vitro by using a rotating cylinder and observed for 8 hours.
The results showed that the tablets of ethanolic extract mango’s leaves variety bapang have characteristics physical are qualified characteristic physical of tablets. Mucoadhesive in vitro test showed that all formulas have good mucoadhesive strenght. Mucoadhesive strenght increased with the increasing of guar gum. The result of this research showed that formula 4 with the highest concentration of guar gum showed the best mucoadhesive strenght that can be attached 7 ± 1 hour.

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