Update Artikelilmiah: 51304

ELGINIA ALZAHRA

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Latar Belakang : Paparan gelombang elektromagnetik (EM) telepon seluler berpotensi meningkatkan stres oksidatif yang berkaitan dengan perubahan metabolisme lipid dan risiko aterogenik. Ekstrak Centella asiatica kaya flavonoid dan triterpenoid dilaporkan bersifat antioksidan dan antiinflamasi sehingga dapat bermanfaat dalam memodulasi profil lipid pada kondisi paparan EM.
Tujuan : Mengetahui pengaruh pemberian ekstak pegagan (Centella asiatica) terhadap kadar HDL dan LDL tikus putih (Rattus norvegicus) yang diberi paparan gelombang elektromagnetik telepon seluler.
Metode : Penelitian ini adalah penelitian true experimental dengan desain post-test only with control group. Tikus Wistar jantan sebanyak 30 ekor dibagi acak menjadi 5 kelompok yaitu K1 (kontrol sehat), K2 (dipapar EM ponsel 4G 2100 MHz melalui panggilan WhatsApp 2 jam/hari selama 45 hari), K3-K5 dipapar EM dengan perlakuan yang sama serta diberi ekstrak Centella asiatica 125,250, dan 500 mg/kgBB/hari per oral 1 jam sebelum paparan. Analisis menggunakan One Way ANOVA (p<0.05) dilanjutkan uji Tukey HSD berpasangan antar kelompok.
Hasil : Rerata HDL (mg/dL) berturut-turut yaitu K1=24.8; K2=34.33; K3=27.83; K4=30.33: K5=41.33. Hasil ANOVA menunjukan perbedaan signifikan antar kelompok (p=0.014). Uji Tukey HSD menunjukkan perbedaan signifikan antara K1 dengan K5 (p=0.014) dan K3 dengan K5 (p=0.043). Rerata LDL (mg/dL) berturut-turut yaitu K1=16.1; K2=14.8; K3=28.7; K4=12.5: K5=19.6. Terdapat perbedaan signifikan (p=0.011) dengan perbandingan signifikan antara K2 dengan K3 (p=0.044) dan K3 dengan K4 (p=0.009).
Kesimpulan : Terdapat pengaruh pemberian ekstrak Centella asiatica terhadap kadar HDL dan LDL pada tikus Wistar jantan yang dipapar gelombang EM. Dosis 500 mg/kgBB paling efektif meningkatkan HDL, sedangkan dosis 250 mg/kgBB paling optimal menurunkan LDL.
Kata kunci : Centella asiatica, Gelombang elektromagnetik, HDL, LDL

Abtrak (Bhs. Inggris)

Background : Exposure to electromagnetic (EM) field from mobile phones potentially increases oxidative stress, which is associated with changes in lipid metabolism and increased atherogenic risk. Centella asiatica extract is rich in flavonoids and triterpenoids and is reported to have antioxidant and anti-inflammatory properties; therefore, it may be beneficial in modulating lipid profiles under EM exposure.
Objective : to determine the effect of Centella asiatica extract on HDL and LDL levels in white rats (Rattus norvegicus) exposed to electromagnetic waves from mobile phones.
Methods : This study was a true experimental study using a post-test only control group design. Thirty male Wistar rats were randomly allocated into five groups: K1 (healthy control), K2 (exposed to 4G mobile-phone EM field at 2100 MHz via WhatsApp calls for 2 hours/day for 45 days), and K3-K5 (exposed to the same EM protocol and administered oral Centella asiatica extract at doses of 125, 250, and 500 mg/kg body weight/day. Data were analyzed using one-way ANOVA (p < 0.05), followed by Tukey’s HSD post-hoc test for pairwise comparisons.
Results : The mean HDL levels (mg/dL) are K1=24.8, K2=34.33, K3=27.83, K4=30.33, and K5=41.33. A significant difference is observed among groups (p=0.014). Tukey’s HSD test shows a significant difference between K1 and K5 (p=0.014) and between K3 and K5 (p=0.043). The mean LDL levels (mg/dL) are K1=16.1, K2=14.8, K3=28.7, K4=12.5, and K5=19.6. A significant difference is observed among groups (p=0.011), with significant pairwise differences between K2 and K3 (p= 0.044) and between K3 and K4 (p=0.009).
Conclusion : Administration of Centella asiatica extract affects HDL and LDL levels in male Wistar rats exposed to EM field. A dose of 500 mg/kg body weight is the most effective in increasing HDL, whereas a dose of 250 mg/kg body weight is the most optimal in reducing LDL.

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