Update Artikelilmiah: 51131

MUHAMMAD FIRMAN IHRAMI

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Latar Belakang: Karsinoma mammae subtipe luminal B HER2-negative memiliki proliferasi tinggi yang dapat dinilai melalui ekspresi Ki-67 dan respons imun tumor yang dapat dilihat dari Tumor Infiltrating Lymphocytes (TILs). Hubungan keduanya masih belum konsisten.Tujuan: Mengetahui hubungan ekspresi Ki-67 terhadap densitas TILs pada pasien karsinoma mammae subtipe luminal B HER2-negative di RSUD Prof. Dr. Margono Soekarjo.Metodologi: Penelitian observasional analitik dengan desain cross-sectional menggunakan total sampling pada data rekam medis periode 2023–2024. Data Ki-67 diperoleh dari imunohistokimia dan densitas TILs dari histopatologi. Analisis menggunakan uji Chi-Square.Hasil: Sebanyak 89 sampel memenuhi kriteria inklusi. Ekspresi Ki-67 tinggi ditemukan pada 61,8% sampel dan TILs rendah pada 43,8% sampel. Uji Chi-Square menunjukkan tidak terdapat hubungan bermakna antara ekspresi Ki-67 dan densitas TILs (p = 0,410).Kesimpulan: Tidak terdapat hubungan signifikan antara ekspresi Ki-67 dan densitas TILs pada karsinoma mammae subtipe luminal B HER2-negative.

Abtrak (Bhs. Inggris)

Background: Luminal B HER2-negative breast cancer is characterized by high proliferation, commonly assessed by Ki-67 expression, while tumor immune response can be evaluated through tumor-infiltrating lymphocytes (TILs). The relationship between Ki-67 and TILs remains inconsistent.Objective: To determine the association between Ki-67 expression and TILs density in luminal B HER2-negative breast cancer patients at RSUD Prof. Dr. Margono Soekarjo.Methods: This observational analytic study used a cross-sectional design with total sampling of medical records from 2023–2024. Ki-67 expression was obtained from immunohistochemistry, and TILs density was assessed from histopathological examination. Data were analyzed using the Chi-Square test.Results: A total of 89 samples met the inclusion criteria. High Ki-67 expression was found in 61.8% of cases, while low TILs density was observed in 43.8%. Chi-Square analysis showed no significant association between Ki-67 expression and TILs density (p = 0.410).Conclusion: There was no significant association between Ki-67 expression and TILs density in luminal B HER2-negative breast cancer patients.

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