Update Artikelilmiah: 51085

RAUDHA SHAFA' HERDANTY

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Latar Belakang: Paparan gelombang elektromagnetik dari telepon seluler dapat memicu stres oksidatif yang berdampak buruk bagi kesehatan, termasuk mempengaruhi jumlah eritrosit dan kadar hemoglobin. Centella asiatica memiliki aktivitas antioksidan yang berpotensi melindungi sel darah dari kerusakan tersebut. Tujuan: Mengetahui pengaruh pemberian ekstrak pegagan (Centella asiatica) terhadap jumlah eritrosit dan kadar hemoglobin tikus putih (Rattus norvegicus) yang terpapar elektromagnetik telepon seluler. Metode Penelitian: Penelitian ini menggunakan metode true experimental dengan desain post-test only control group pada 30 tikus Wistar jantan yang dibagi menjadi 5 kelompok. Kelompok 1 menjadi kontrol tanpa ekstrak Centella asiatica dan tanpa paparan elektromagnetik. Kelompok 2 mendapat paparan elektromagnetik telepon seluler 2100 MHz selama 2 jam/hari melalui panggilan WhatsApp. Kelompok 3, 4, dan 5 diberikan ekstrak Centella asiatica (125, 250, 500 mg/kgBB) sebelum paparan. Jumlah eritrosit dan kadar hemoglobin diukur menggunakan Hematology Analyzer dan data dianalisis dengan uji One Way ANOVA dan ANOVA Welch. Hasil: Rerata jumlah eritrosit kelompok 1=7,43 juta/μL, 2=8,28 juta/μL, 3= 8,07 juta/μL, 4=6,51 juta/μL, dan 5=6,69 juta/μL . Rerata kadar hemoglobin kelompok 1=13,7 g/dL, 2=14,8 g/dL, 3=14,6 g/dL, 4=12,1 g/dL, dan 5=12,15 g/dL. Uji One Way ANOVA jumlah eritrosit menunjukkan p=0,000 dan uji ANOVA Welch kadar hemoglobin menunjukkan nilai p=0,002. Kesimpulan: Pemberian ekstrak pegagan (Centella asiatica) memberikan pengaruh signifikan terhadap jumlah eritrosit dan kadar hemoglobin tikus putih (Rattus norvegicus) yang terpapar elektromagnetik telepon seluler.

Abtrak (Bhs. Inggris)

Background: Exposure to electromagnetic waves from mobile phones triggered oxidative stress that adversely affected health, including altering erythrocyte count and hemoglobin levels. Centella asiatica possessed antioxidant activity that might have protected blood cells from such damage. Objective: To determine the effect of Centella asiatica extract on erythrocyte count and hemoglobin levels in white rats (Rattus norvegicus) exposed to mobile phone electromagnetic. Method: This study used a true experimental with a post-test only control group design on 30 male Wistar rats that were divided into five groups. Group 1 was the control without Centella asiatica extract and without electromagnetic exposure. Group 2 received 2100 MHz mobile phone electromagnetic exposure for 2 hours/day through a WhatsApp call. Groups 3, 4, and 5 were given Centella asiatica extract (125, 250, 500 mg/kgBW) before exposure. Erythrocyte count and hemoglobin levels were measured using a Hematology Analyzer, and the data were analyzed using One Way ANOVA and Welch ANOVA. Results: The mean erythrocyte counts for groups 1, 2, 3, 4, and 5 are 7.43 million/μL, 8.28 million/μL, 8.07 million/μL, 6.51 million/μL, and 6.69 million/μL. The mean hemoglobin levels for groups 1, 2, 3, 4, and 5 are 13.7 g/dL, 14.8 g/dL, 14.6 g/dL, 12.1 g/dL, and 12.15 g/dL. The One-Way ANOVA test for erythrocyte count shows p-values=0,000 and the Welch ANOVA test for hemoglobin level show p-values=0,002. Conclusion: Administration of Centella asiatica extract has a significant effect on erythrocyte count and hemoglobin levels in white rats (Rattus norvegicus) exposed to mobile-phone electromagnetic.

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