Update Artikelilmiah: 48994

AISY PRITA SYAFINA

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Abstrak (Bhs. Indonesia)

Sepsis merupakan respons inflamasi sistemik akibat infeksi yang dapat menyebabkan kegagalan organ multipel dan kematian. Penelitian ini bertujuan mengevaluasi kesesuaian antibiotik empiris terhadap luaran terapi pasien sepsis dewasa. Studi observasional retrospektif dilakukan di RSUD Prof. Dr. Margono Soekarjo Purwokerto tahun 2024 dengan total sampling terhadap 57 pasien. Kesesuaian antibiotik dinilai berdasarkan antibiogram RS, PNPK Sepsis 2017, IDSA 2020, dan DIH 2021. Luaran terapi dievaluasi secara klinis; analisis bivariat menggunakan uji Chi-Square. Mayoritas pasien menerima kombinasi Ceftazidime + Levofloxacin (64,90%). Tingkat kesesuaian berdasarkan antibiogram 71,43%, guideline terapi 47,37%, dan dosis 17,86%. Tidak ditemukan hubungan signifikan antara kesesuaian antibiotik empiris dan luaran terapi (p > 0,05). Meski tingkat kesesuaian masih rendah, terapi yang tepat cenderung memberikan luaran lebih baik. Penggunaan antibiogram secara konsisten penting untuk efektivitas terapi dan pencegahan resistensi.

Abtrak (Bhs. Inggris)

Sepsis is a systemic inflammatory response to infection that can lead to multiple organ failure and death. This study aimed to evaluate the appropriateness of empiric antibiotik therapy and its relationship with clinical outcomes in adult sepsis patients. A retrospective observational study was conducted at Prof. Dr. Margono Soekarjo Hospital in 2024, involving 57 patients selected through total sampling. Antibiotic appropriateness was assessed based on the hospital’s antibiogram, the 2017 Indonesian Sepsis Guidelines, IDSA 2020, and DIH 2021. Clinical outcomes were evaluated using general and specific parameters; bivariate analysis was performed using the Chi-Square test. Most patients received a combination of Ceftazidime + Levofloxacin (64.90%). Antibiotic appropriateness based on antibiogram was 71.43%, therapeutic guidelines 47.37%, and correct dosing 17.86%. No significant association was found between empiric antibiotik appropriateness and clinical outcomes (p > 0.05). Although overall appropriateness was low, proper therapy tended to result in better outcomes. Consistent use of the antibiogram is essential to improve treatment effectiveness and reduce the risk of antibiotik resistance.

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