Update Artikelilmiah: 48992

PUTRI APRILIASARI

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Abstrak (Bhs. Indonesia)

Peresepan antibiotik yang sesuai dengan guideline terapi dan pola resistensi bakteri diperlukan untuk mengoptimalkan terapi pada pasien Community-acquired pneumonia (CAP). Penelitian bertujuan untuk mengevaluasi peresepan dan pendosisan antibiotik empiris serta hubungannya terhadap clinical outcome pasien CAP anak di RSUD Margono. Penelitian ini bersifat observasional deskriptif dan pendekatan retrospektif yang diperoleh dari data rekam medis pasien CAP anak periode Juli – Desember 2024. Pengumpulan data dilakukan secara total sampling serta analisis dengan uji Chi-square. Hasil diperoleh mayoritas dari 93 pasien diberikan antibiotik tunggal (64%) dengan antibiotik paling banyak berupa ceftriaxone (39,2%). Tingkat kesesuaian peresepan antibiotik empiris berdasarkan guideline terapi sebesar 83,2% dan antibiogram 3,4% serta kesesuaian pendosisan 58,8%. Sebagian besar pasien memperoleh clinical outcome membaik (87%). Uji statistik menunjukkan tidak terdapat hubungan signifikan antara kesesuaian peresepan dan pendosisan antibiotik empiris terhadap clinical outcome pasien (p=0,072; p=0,892; p>0,05). Kesesuaian peresepan dan pendosisan antibiotik empiris pada pasien CAP anak di RSUD Margono memperlihatkan persentase clinical outcome membaik yang lebih besar, meskipun secara statistik tidak menunjukkan hubungan signifikan.

Abtrak (Bhs. Inggris)

Abstract
Antibiotic prescribing in accordance with treatment guidelines and bacterial resistance patterns is necessary to optimize treatment in patients with community-acquired pneumonia (CAP). The study aimed to evaluate empirical antibiotic prescribing and dosing and their relationship to clinical outcomes in pediatric CAP patients at Margono General Hospital. This study is an observational descriptive study using a retrospective approach, based on medical records of pediatric CAP patients from July to December 2024. Data collection was conducted using total sampling, and analysis was performed using the Chi-square test. The results showed that the majority of 93 patients were prescribed single antibiotics (64%), with ceftriaxone being the most commonly prescribed antibiotic (39.2%). The compliance rate of empirical antibiotic prescriptions based on treatment guidelines was 83.2%, antibiogram compliance was 3.4%, and dosage compliance was 58.8%. Most patients achieved improved clinical outcomes (87%). Statistical analysis showed no significant association between the appropriateness of empirical antibiotic prescribing and dosing and patient clinical outcomes (p=0.072; p=0.892; p>0.05). The compliance of empirical antibiotic prescriptions and dosing in pediatric CAP patients at Margono General Hospital showed a higher percentage of improved clinical outcomes, although statistically no significant association was demonstrated.

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