Update Artikelilmiah: 48164

RIZQI AMALIA SUNARYONO

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Latar Belakang. Anak talasemia beta mayor berisiko tinggi mengalami karies 
akibat gangguan fungsi saliva dan stres oksidatif. Karies dapat disebabkan oleh 
kurangnya peran superoksida dismutase sebagai antioksidan dalam melindungi gigi 
dari stres oksidatif. Stres oksidatif yang tinggi diduga berhubungan dengan kadar 
serum feritin sebagai indikator jumlah zat besi dalam tubuh. Tujuan. Penelitian ini 
bertujuan untuk mengetahui hubungan kadar serum feritin dan SOD saliva dengan 
kejadian karies  pada anak talasemia beta mayor. Metode. Penelitian cross
sectional dengan sampel 50 penyintas talasemia beta mayor usia 12-15 tahun di 
Instalasi Pelayanan Talasemia Terpadu RSUD Banyumas. Kadar SOD saliva diukur 
menggunakan spektrofotometer UV-Vis, kadar serum feritin diperoleh dari rekam 
medis, dan kejadian karies dinilai dengan indeks DMF-T. Analisis statistik 
dilakukan dengan uji korelasi bivariat Pearson Product Moment. Hasil. Rerata 
kadar SOD saliva adalah 161,97 U/mL (lebih rendah dari normal), rerata kadar 
serum feritin 5.580,92 ng/mL (lebih tinggi dari normal), dan rerata DMF-T 
penyintas talasemia beta mayor 7,52 (kategori karies sangat tinggi). Hasil penelitian 
menunjukkan tidak terdapat korelasi antara kadar serum feritin dengan kejadian 
karies gigi (r= 0,214 p= 0,136), terdapat korelasi negatif signifikan antara SOD 
saliva dengan karies gigi (r= -0,430; p= 0,002), dan terdapat korelasi negatif 
signifikan antara serum feritin dan SOD saliva (r= -0,690; p= 0,001). Simpulan. 
Rendahnya SOD saliva berhubungan dengan kejadian karies gigi, sementara kadar 
serum feritin tidak berhubungan langsung dengan kejadian karies gigi, namun kadar 
serum feritin berhubungan dengan kadar SOD saliva. Temuan ini menekankan 
perlunya evaluasi rutin kadar SOD saliva serta upaya preventif karies  pada anak 
talasemia beta mayor. 
Kata kunci: Karies gigi, serum feritin, stres oksidatif, superoksida dismutase 
saliva, talasemia beta mayor

Abtrak (Bhs. Inggris)

Background: Children with beta-thalassemia major are highly susceptible to dental 
caries due to impaired salivary function and increased oxidative stress. A deficiency 
in superoxide dismutase (SOD), a key antioxidant enzyme in saliva, may contribute 
to caries development by failing to protect against oxidative damage. Oxidative 
stress is suspected to correlate with elevated serum ferritin, an indicator of iron 
overload. Purpose: To examine the relationship between serum ferritin levels, 
salivary SOD levels, and dental caries in children with beta-thalassemia major. 
Methods: This cross-sectional study involved 50 beta-thalassemia major survivors 
aged 12–15 years at the Integrated Thalassemia Service Unit, Banyumas General 
Hospital. Salivary SOD levels were measured using a UV-Vis spectrophotometer, 
serum ferritin data were retrieved from medical records, and caries were assessed 
using the DMF-T index. Data were analyzed using Pearson’s correlation test. 
Results: The mean salivary SOD level was 161.97 U/mL (below normal), serum 
ferritin was 5,580.92 ng/mL (above normal), and the mean DMF-T score was 7.52 
(very high). No significant correlation was found between serum ferritin and caries 
incidence (r = 0.214; p = 0.136). However, a significant negative correlation was 
observed between salivary SOD and caries (r = –0.430; p = 0.002), and between 
serum ferritin and salivary SOD (r = –0.690; p = 0.001). Conclusion: Low salivary 
SOD levels are associated with increased caries in children with beta-thalassemia 
major. While serum ferritin does not directly correlate with caries, it is significantly 
linked to salivary SOD levels. Monitoring SOD levels and preventive dental care 
are strongly recommended. 
Keywords: Beta-thalassemia major, dental caries, salivary superoxide dismutase, 
serum ferritin, oxidative stress

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