Update Artikelilmiah: 35983

ARDILA PUTRI YUWANTI

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Abstrak (Bhs. Indonesia)

Spray gel minyak atsiri bunga lavender merupakan alternatif yang dapat digunakan sebagai antiseptik. Minyak atsiri bunga lavender memiliki kandungan linalool dan linalil asetat yang memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk mendapatkan formula terbaik sediaan spray gel antiseptik yang memiliki sifat fisik dan stabilitas fisik serta memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Penelitian eksperimental ini meliputi pembuatan sediaan spray gel, evaluasi sifat fisik dan stabilitas fisik serta uji aktivitas antibakteri. Spray gel diformulasikan dengan variasi HPMC pada konsentrasi 0,05%; 0,1%; 0,25; dan 0,5%. Pengamatan organoleptik, homogenitas, kondisi semprotan, dan stabilitas fisik dianalisis secara deskriptif. Pengamatan pH, daya sebar lekat, viskositas dianalisis dengan oneway ANOVA. Formula terpilih kemudian diuji aktivitas antibakteri terhadap S. aureus. Hasil penelitian menunjukkan bahwa formula I memenuhi persyaratan sifat fisik dan uji stabilitas fisik  freeze-thaw. Formula I merupakan formula terbaik pada pengujian daya lekat dan kondisi semprotan. Formula terpilih sediaan spray gel menunjukkan bahwa formula I memiliki aktivitas antibakteri terhadap S. aureus lebih besar dibandingkan dengan kontrol positif (sedian spray gel komersil merk X yang mengandung alcohol 70%) yaitu diameter zona hambat pada formula terpilih sebesar 5,6 mm sedangkan pda control positif sebasesar 1,1 mm.

Abtrak (Bhs. Inggris)

Lavender essential oil spray gel is an alternative that can be used as an antiseptic. Lavender essential oil contains linalool and linalyl acetate which have antibacterial activity. This study aims to obtain the best formula for antiseptic spray gel preparations that have physical properties and physical stability and have antibacterial activity against Staphylococcus aureus. This experimental research includes the manufacture of spray gel preparations, evaluation of physical properties and physical stability as well as antibacterial activity tests. Spray gel is formulated with variations of HPMC at a concentration of 0.05%; 0.1%; 0.25; and 0.5%. Organoleptic, homogeneity, spray conditions, and physical stability were analyzed descriptively. Observation of pH, stickiness spreadability, viscosity were analyzed by one-way ANOVA. The selected formula was then tested for antibacterial activity against S. aureus. The results showed that Formula I (0.05% HPMC concentration) met the requirements for physical properties and freeze-thaw physical stability tests. Formula I is the best formula in testing the adhesion dispersion and spray conditions. The selected formula for spray gel preparations showed that formula I had greater antibacterial activity against S. aureus than the positive control (commercial spray gel of brand X containing 70% alcohol),  the diameter of the inhibition zone in the selected formula was 5.6 mm, while the control  positive was 1.1 mm.

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