Update Artikelilmiah: 32654

FRESHYAMA DANIAR ROSY

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Penyakit Paru Obstruktif Kronik (PPOK) dapat dikaitkan dengan paparan polutan udara yang melebihi nilai ambang batas yang dapat menyebabkan inflamasi paru yang ditandai dengan pelepasan mediator pro-inflamasi seperti Macrophage Inflammatory Protein-2 (MIP-2). Penelitian ini bertujuan untuk mengetahui hubungan paparan polutan udara dengan kadar MIP-2 pada pekerja informal di Purwokerto. Desain penelitian adalah cross-sectional yang merekrut 35 pekerja parkir outdoor sebagai subjek penelitian dan 35 pekerja informal indoor sebagai subjek pembanding. Hasil penelitian menunjukkan bahwa tidak ada hubungan antara paparan kadar debu dengan kadar MIP-2 baik di outdoor (r=0,03; p=0,85), indoor (r=-0,31; p=0,07), maupun secara total (r= 0,20; p=0,09). Paparan polutan udara di outdoor lebih tinggi daripada di indoor (p=0,00). Kadar MIP-2 pada pekerja outdoor lebih tinggi dibandingkan pekerja indoor (p=0,00). Durasi kerja secara keseluruhan dan per hari tidak dikaitkan dengan tingkat MIP baik untuk outdoor maupun indoor, serta untuk total pekerja. Analisis multivariat menunjukkan bahwa tidak ada hubungan antara durasi paparan dengan kadar MIP-2 jika disesuaikan dengan usia, paparan debu, dan status merokok. Kesimpulannya, paparan polutan udara pada pekerja informal di Purwokerto berupa kadar debu secara konsisten tidak terkait dengan MIP-2 mereka. Namun, perbedaan signifikan ditemukan pada paparan debu dan kadar MIP-2 antara pekerja di outdoor dibandingkan dengan pekerja di indoor.

Abtrak (Bhs. Inggris)

Chronic Obstructive Pulmonary Disease (COPD) can be associated with exposure to air pollutants that exceed the threshold value which can lead to lung inflammation which is characterized by the release of pro-inflammatory mediators such as Macrophage Inflammatory Protein-2 (MIP-2). This study aimed to determine the association between air pollutant exposure and MIP-2 levels in informal workers in Purwokerto. The study design was cross-sectional recruited 35 outdoor parking workers as study subjects and 35 indoor informal workers as comparison subjects. Results showed that there was no association between exposure to dust levels and MIP-2 levels both in outdoor (r=0.03; p=0.85), indoor (r=-0.31; p=0.07), as well as in total (r=0.20; p=0.09). Exposure to air pollutants in outdoor was higher than indoor (p=0.00). MIP-2 levels in outdoor workers were higher than indoor workers (p=0.00). Working duration in overall and per day were not asssociated to MIP levels for both outdoor and indoor, as well as for total workers. Multivariate analysis showed that there was no association between exposure duration and MIP-2 levels when adjusted to age, dust exposure, and smoking status. As conclution, exposure to air pollutants to informal workers in Purwokerto, in the form of dust levels is consistently not associated with their MIP-2. However, significant differences were found in dust exposure and MIP-2 levels between outdoor workers compared to indoor workers.

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