Update Artikelilmiah: 31858

ENOK NINA NURAENI

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Abstrak (Bhs. Indonesia)

Latar Belakang: Tingginya kadar Low Density Lipoprotein (LDL) merupakan salah satu tanda hiperkolesterolemia. Kombinasi seduhan bawang dayak dan madu berpotensi menurunkan kadar LDL. Tujuan penelitian untuk mengetahui pengaruh kombinasi seduhan bawang dayak dan madu terhadap penurunan kadar LDL pada tikus model hiperkolesterolemia.

Metode: Penelitian ini menggunakan true experimental pre and post test with control group design. Kombinasi seduhan bawang dayak dan madu diberikan  selama 14 hari. Sampel berjumlah 30 ekor tikus dikelompokan menjadi enam kelompok yaitu kontrol sehat (A), kontrol sakit (B), perlakuan (C, D, dan E) diberi seduhan bawang dayak dosis 100 mg/kgBB, 200 mg/kgBB, 400 mg/kgBB yang dikombinasikan dengan madu 1 ml/kgBB. Kontrol positif (F) diberi simvastatin 0,9 mg/kgBB. Analisis data kadar LDL pretest dan selisih menggunakan One-way ANOVA dan post hoc Duncan, sedangkan post-test menggunakan Welch’s ANOVA dan post hoc Games-Howell.

Hasil Penelitian: Hasil One-way ANOVA selisih kadar LDL menunjukkan kombinasi seduhan bawang dayak dan madu berpengaruh terhadap penurunan kadar LDL (p<0,05). Hasil uji post hoc Duncan terdapat perbedaan signifikan antar kelompok kecuali kelompok D, E, dan F.

Kesimpulan: Kombinasi seduhan bawang dayak 200 mg/kgBB dan madu 1 ml/kgBB merupakan dosis paling efektif untuk menurunkan kadar LDL.

Abtrak (Bhs. Inggris)

Background: High levels of Low Density Lipoprotein (LDL) are a sign of hypercholesterolemia. The combination of steeped Dayak onions and honey have potential to reduce LDL levels. The aim of  this research to know the effect by giving steeped of Dayak onion and honey towards the decreasing  of LDL level in hypercholesterolemia rats model.

Method: The research used true experimental pre and post test with control group design.  The combination of steeped Dayak onions and honey for 14 days. The sample used 30 rats were divided into 6 groups consisting of healthy control (A), sick control (B), treatment (C, D, and E) was given stepeed of Dayak onions each dose of 100 mg/ kgBW, 200 mg/kgBW, 400 mg/kgBW combined with honey 1 ml /kgBW. Positive control (F) was given simvastatin 0.9 mg /kgBW. Data analysis of pretest and difference LDL levels used One-way ANOVA and post hoc Duncan, while post-test used Welch's ANOVA and post hoc Games-Howell.

Results: The result of One-way ANOVA showed that the combination of stepeed Dayak onion and honey had an effect on reducing LDL levels (p <0.05). The results of Duncan's post hoc test showed significant differences between groups except groups D, E, and F.

Conclusion: The combination of  stepeed Dayak onions 200 mg/kgBW and honey 1 ml/kgBW were the most effective dosage to decreasing LDL level.

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