Update Artikelilmiah: 26722

KHOIRUN NISA'

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Minyak serai wangi memiliki kandungan citronella yang dapat dijadikan sebagai zat aktif sampo antiketombe terhadap Pityrosporum ovale. HPMC dapat digunakan sebagai thickening agent. Kombinasi surfaktan yang digunakan yaitu sodium lauril sulfat (SLS) dan Cocamide DEA yang dapat meningkatkan kualitas foaming serta menstabilkan busa. Untuk menghasilkan sampo gel yang memenuhi syarat dan dapat diterima oleh masyarakat, perlu dilakukan optimasi formula. Optimasi dilakukan dengan metode simplex lattice design (SLD) dengan 3 komponen yaitu, HPMC (A), SLS (B), dan cocamide DEA (C). Parameter optimasi yang digunakan yaitu viskositas, kemampuan dan stabilitas busa, persentase zat padat, dan pH. Sampo gel minyak serai wangi dibuat dengan variasi konsentrasi HPMC 1,5%, 2,1%, 2,5%, dan 3,5% ; SLS 13%, 13,67%, 14%, 15% ; Cocamide DEA 2%, 2,67%, 3%, 4%. Berdasarkan persamaan SLD, dibuat  contour plot dan superimpossed contour plot untuk menentukan formula optimum. Formula optimum kemudian diuji aktivitas antifungi terhadap P.ovale dan dianalisis menggunakan One way Anova. Berdasarkan superimposed contour plot  diperoleh  formula  optimum dengan  proporsi minyak serai wangi konsentrasi 1200 ppm dapat diformulasikan menjadi sampo antiketombe dengan basis HPMC 1,5%, SLS 13%, Cocamide DEA 4%, propil paraben 0,2%, dan mentol 0,25% . Respon pH dipengaruhi oleh komponen Cocamide DEA, Viskositas dipengaruhi oleh HPMC. Sedangkan volume busa dan persentase zat padat dipengaruhi oleh SLS. Formula optimum memiliki aktivitas antifungi terhadap P. ovale dengan dengan diameter zona hambat kategori kuat 15,1 ± 1,25 mm

Abtrak (Bhs. Inggris)

Citronella essential oil contains citronella which can be made as shampoo for dandruff treatment caused by Pityrosporum ovale. HPMC can be used for thickening agent and foam stabilizer. The combination of surfactans used are sodium lauryl sulfate (SLS) and Cocamide DEA that can improve the quality of foaming and stabilize the foam.In order to produce shampoo that is qualified and acceptable to the community, it needs to be done formula optimization. The research was done by simplex lattice design (SLD) method with 3 components, i.e CMC (A), SLS (B), and Cocamide DEA (C). The optimization parameters of gel shampoo were viscosity, ability and stability of foam, percentage of solid content, and pH. Citronella essential oil gel shampoo was made with the variation of HPMC 1,5%, 2,1%, 2,5%, 3,5% ; SLS 13%, 13,67%, 14%, 15% ; Cocamide DEA 2%, 2,67%, 3%, 4%. Based on the SLD model, contour plot and superimposed contour plot was created to determine the optimum formula. Optimum formula, then tested the antifungal activity against P. ovale and analyzed using One Way Anova.  Based on  superimposed contour plot was obtained with the proportion of 
citronella essential oil concentration of 1200 ppm can be formulated into antidandruff shampoo with HPMC 1,5%, SLS 13%, Cocamide DEA 4%, propyl paraben 0,2%, and menthol 0,25%. The pH response is affected by the Cocamide DEA component, viscosity is influenced by HPMC. While the volume of foam and the percentage of solid substances is influenced by SLS. Optimum Formula has antifungi activity against P. Ovale with the diameter of a strong zone of the category 15.1 ± 1.25 mm.

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