Update Artikelilmiah: 23126

ELLY WULANDARI

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Monosodium glutamate (MSG) ialah bubuk kristal berwarna putih yang sejak lama telah digunakan sebagai bahan aditif pada beragam jenis makanan di berbagai negara. Efek MSG terhadap kesehatan manusia masih kontroversi .Berbagai penelitian pada hewan coba menunjukkan bahwa pemberian MSG pada periode neonatal atau infant dapat berpengaruh negatif terhadap perkembangan hewan uji. Penelitian ini bertujuan mengetahui efek pemberian MSG selama masa kebuntingan mencit terhadap perkembangan morfologi embrio, fetus dan neonatus. Data diambil pada 8 dpc, 14 dpc dan  hari pertama post natal. Data kuantitatif berupa panjang crown to rump embrio, fetus dan neonatus; berat tubuh embrio, fetus dan neonatus diuji normalitasnya dan homogenitasnya, dilanjutkan dengan uji Anova satu arah dan uji lanjut Post Hoc Tukey (HSD) menggunakan SPSS versi 23. Data kualitatif berupa kenormalan morfologi vesikula otak embrio, kaki fetus dan neonatus dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa pemberian MSG pada induk mencit selama periode kebuntingan dengan dosis MSG 1,25 ; 2,5 dan 5 mg/G BB menghambat pertumbuhan embrio pada minggu pertama namun efek tersebut tidak berlanjut hingga kelahiran. MSG pada dosis uji mengakibatkan gangguan pada pembentukan vesikula otak (umur 8 dpc), memperlambat perkembangan membra (14 dpc) dan menurunkan jumlah anak

Abtrak (Bhs. Inggris)

Monosodium glutamate (MSG) is a white crystalline powder that has been used as an additive in various foods in many countries. The effect of MSG is still controvercy on human health. Several animal studies have shown that administration of MSG in the neonatal or infant period can negatively affect the development of test animals. This study aims to determine the effect of MSG administration during mice pregnancy on the morphological development of embryo, fetus and neonates.. Data was collected on 8 dpc, 14 dpc and first day post partum. Quantitative data in the form of crown to rump length embryos, fetuses and neonates; the body weight of the embryo, fetus and neonates was tested for its normality and homogeneity, followed by a one-way Anova test and post Hoc Tukey (HSD) follow-up test using SPSS version 23. Qualitative data in the form of vesicular morphology normality of the embryo, fetal and neonatal brain were analyzed descriptively. The results showed that the administration of MSG to the gravid mice during the pregnancy period with MSG dose of 1.25; 2.5 and 5 mg / g BW inhibit growth of the embryo but the effect was recovered as the pregnancy. MSG at the tested doses results in brain vesicle formation ( 8 dpc), slowed down  fetal development (14 dpc) and decreased the number of letters.

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