Update Artikelilmiah: 21271

AULIYA SYISMA AGHNESI

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Latar Belakang: Antibiotik merupakan salah satu penatalaksanaan infeksi karena bakteri. Penggunaan antibiotik saat ini sering kali tidak rasional, sehingga menyebabkan resistensi.Resistensi antibiotik meningkatkan morbiditas dan mortalitas serta meningkatkan biaya perawatan akibat lama tinggal di rumah sakit dan kebutuhan akan obat-obatan. Untuk mengoptimalkan penggunaan antibiotik dan mencegah resistensi bakteri terhadap antibiotik, diperlukan informasi mengenai pola kuman patogen dan sensitivitasnya terhadap antibiotik Tujuan: Penelitian ini bertujuan untuk mengetahui pola sensitivitas kuman terhadap antibiotik di RSUD Prof. Dr. Margono Soekarjo. Metode: Penelitian ini merupakan penelitian observasional deskriptif terhadap 2094 isolat kultur dan hasil uji sensitivitas antibiotik dari 1469 pasien yang diambil dari catatan laboratorium Patologi Klinik RSUD Prof. Dr. Margono Soekarjo periode tahun 2016. Data diolah dengan menggunakan software WHONET 5.6.. Hasil: Hasil penelitian ini adalah pola sensitivitas antibiotik sepuluh bakteri penyebab infeksi, yaitu Klebsiella pneumoniae ss. pneumoniae sensitif terhadap antibiotik amikasin, meropenem, ertapenem, dan tigecyclin. Escherichia coli sensitif terhadap amikasin, meropenem, piperasilin-tazobaktam, ertapenem,cefotaxime, tigecyclin, dan nitrofurantoin. Staphylococcus aureus ss. aureus sensitif terhadap gentamisin, oksasilin, ciprofloxacin, levofloxacin, moxifloxacin, tigecyclin,
trimetoprim-sulfametoksazol, klindamisin, eritromisin, linezolid, quinupristin-dalfopristin, vankomisin, dan nitrofurantoin. Pseudomonas aeruginosa sensitif terhadap amikasin, gentamisin, meropenem, dan cefepime. Acinetobacter baumannii sensitif terhadap amikasin, meropenem, dan tigecyclin. Staphylococcus haemolyticus sensitif terhadap tigecyclin, linezolid, quinupristin-dalfopristin, vankomisin, dan nitrofurantoin. Enterobacter cloacae sensitif terhadap amikasin, meropenem, ertapenem, dan tigecyclin. Staphylococcus hominis ss. hominis sensitif terhadap gentamisin, tigecyclin, linezolid, quinupristin-dalfopristin, vankomisin, dan nitrofurantoin. Proteus mirabilis sensitif terhadap amikasin, meropenem, piperasilin-tazobaktam, dan ertapenem. Enterococcus faecalis sensitif terhadap ampisilin, tigecyclin, linezolid, vankomisin, dan nitrofurantoin.

Abtrak (Bhs. Inggris)

Background: Antibiotics is one of treatment of bacterial infections. The current use of antibiotics is often irrational, causing antibiotic resistance. Antibiotic resistance increases the morbidity and mortality and contributes rising costs of care due to prolonged hospital stays and the need for medication. Information of microbial pattern and its antibiotic susceptibility is required to optimize the use of antibiotics and prevent antibiotics resistance. Objective: This study was aim to to determine antibiotics susceptibility of microorganism in RSUD. Prof. Dr. Margono Soekarjo. Method: This study was a descriptive observational study of 2094 culture isolates and antibiotic susceptibility test result from 1469 patients taken from Clinical Pathology laboratory records during 2016 period. Data was processed using WHONET 5.6. Result: The results of this study showed antibiotic susceptibility of ten bacteria that cause infection. Klebsiella pneumoniae ss. pneumoniae was sensitive to amikacin, meropenem, ertapenem, and tigecyclin. Escherichia coli was sensitive to amikacin, meropenem, piperacillintazobactam, ertapenem, cefotaxime, tigecyclin, and nitrofurantoin. Staphylococcus aureus ss. aureus was sensitive to gentamicin, oxacillin, ciprofloxacin, levofloxacin, moxifloxacin, tigecyclin, trimethoprim-sulfamethoxazole, clindamycin, erythromycin, linezolid, quinupristin-dalfopristin, vancomycin, and nitrofurantoin. Pseudomonas aeruginosa was sensitive to amikacin, gentamicin, meropenem, and cefepime. Acinetobacter baumannii was sensitive to amikacin, meropenem, and tigecyclin. Staphylococcus haemolyticus was sensitive to tigecyclin, linezolid, quinupristin-dalfopristin, vancomycin, and nitrofurantoin.Enterobacter cloacae was sensitive to amikacin, meropenem, ertapenem, and tigecyclin. Staphylococcus hominis ss. hominis was sensitive to gentamicin, tigecyclin, linezolid, quinupristin-dalfopristin, vancomycin, and nitrofurantoin. Proteus mirabilis was sensitive
to amikacin, meropenem, piperacillin-tazobactam, and ertapenem. Enterococcus faecalis was sensitive to ampicillin, tigecyclin, linezolid, vancomycin, and nitrofurantoin.

Kata kunci

Pembimbing 1

Pembimbing 2

Pembimbing 3

Tahun

Jumlah Halaman