Update Artikelilmiah: 18172

MUHAMMAD EDO ANTARIKSA PRADOTO

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Abstrak (Bhs. Indonesia)

Latar belakang. Preeklamsia merupakan sindrom obstetri yang mempengaruhi 5-10% wanita hamil dan menjadi penyebab morbiditas dan mortalitas maternal maupun perinatal di negara berkembang. Ketidakseimbangan faktor angiogenik khususnya antiangiogenik (sFlt-1) memiliki peranan penting terhadap kejadian preeklamsia.
Tujuan. Untuk mengetahui perbedaan kadar sFlt-1 pada pasien preeklamsia dan pasien dengan kehamilan normotensif serta hubungannya dengan tekanan darah dan proteinuria.
Metode Penelitian. Rancangan penelitian menggunakan pendekatan cross sectional. Subjek penelitian adalah pasien dengan preeklamsia sebanyak 18 subjek dan pasien dengan kehamilan normotensif sebanyak 19 subjek. Analisis statistik menggunakan uji Mann Whitney, ROC, dan Rank Spearman.
Hasil Penelitian. Subjek penelitian menunjukan rerata kadar sFlt-1 pada preeklamsia 11,56 ng/mL dan rerata kadar sFlt-1 pada kehamilan normotensif 7,21 ng/mL. Analisis bivariat kadar sFlt-1 pada kedua kelompok menunjukan perbedaan yang signifikan (p=0,021;Z=-2,311). Cut off point pada kehamilan preeklamsia yaitu 7,71 ng/mL. Terdapat hubungan positif sFlt-1 dengan tekanan darah sistolik (p=0,001;r=0,514). Terdapat hubungan positif sFlt-1 dengan tekanan darah diastolik (p=0,008;r=0,427). Terdapat hubungan positif sFlt-1 dengan proteinuria (p=0,02;r=0,628). 
Kesimpulan. Terdapat perbedaan bermakna kadar sFlt-1 pada preeklamsia dan kehamilan normotensif . Terdapat hubungan bermakna antara kadar sFlt-1 dengan tekanan darah sistolik, tekanan darah diastolik, dan proteinuria.

Abtrak (Bhs. Inggris)

Background. Preeclampsia is a syndrome that affects 5-10% of obstetric pregnant woman and causes of morbidity and maternal and perinatal mortality in developing countries. The imbalance of angiogenic factors in particular antiangiogenic (sFlt-1) has an important role on the incidence of preeclampsia
Objectives. To determine differences in levels of sFlt-1 in patients with preeclampsia and patients with normotensive pregnancies and its association with blood pressure and proteinuria.
Methods. The study design was used cross sectional. Subjects were patients with preeclampsia were 18 subjects and patients with normotensive pregnancies as many as 19 subjects. Statistical analysis was  used Mann Whitney test, ROC, and Spearman Rank.
Result. The subject of research showed the average levels of sFlt-1 in preeclampsia 11.56 ng/mL and the average levels of sFlt-1 in normotensive pregnancies 7.21 ng/mL. Bivariate analyzes levels of sFlt-1 in both groups showed a significant difference (p=0,021;Z=-2,311). Cut off point of preeklamsia pregnancies was 7,71 ng/mL. There was a positive association sFlt-1 with systolic blood pressure (p=0,001;r=0,514). There was a positive association sFlt-1 with diastolic blood pressure (p=0,008;r=0,427). There was a positive association sFlt-1 with proteinuria (p=0,02;r=0,628). 
Coclusions. There were significant differences in the levels of sFlt-1 in preeclampsia and normotensive pregnancies. There was a significant relationship between the levels of sFlt-1 with systolic blood pressure, diastolic blood pressure, proteinuria.

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