Update Artikelilmiah: 17084

DILLA ALFINDA RISDIANA

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Abstrak (Bhs. Indonesia)

Hepatotoksik akibat induksi parasetamol menghasilkan metabolit toksik N-acetyl-p-benzoquinoneimine (NAPQI). Metabolit ini mempunyai efek menstimulasi stres oksidatif yang berpotensi menimbulkan kerusakan sel hepatosit dengan meningkatkan kadar SGOT (Serum Glutamic-Oxaloacetic Transminase) dan SGPT (Serum Glutamic-Pyruvic Transminase). Ekstrak etanol daun sendok (Plantago major L.) memiliki senyawa aktif sebagai antiinflamasi dan antioksidan. Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol daun sendok menurunkan kadar SGPT dan SGOT model hepatotoksik tikus putih (Rattus norvegicus) yang diinduksi parasetamol. Metode penelitian yang digunakan adalah eksperimental dengan rancangan post test only with control group. Dua puluh lima ekor tikus putih jantan dibagi dalam lima kelompok. Kelompok A sebagai kontrol normal diberi akuades. Kelompok B sebagai kontrol negatif diberi parasetamol 128mg/200gBB tikus/hari per oral. Kelompok C, D dan E diberi parasetamol 128mg/200gBB tikus/hari dan ekstrak etanol daun sendok 100mg, 200mg dan 400mg/200gBB tikus/hari per oral. Rerata kadar SGPT kelima kelompok A, B, C, D dan E adalah 86,80±10,01; 118,80±24,42; 98,60±9,40; 116,00±49,68; dan 168,20±121,99. Sedangkan, rerata kadar SGOT kelima kelompok A, B, C, D dan E adalah 164,80±21,95; 201,40±53,94; 165,60±10,29; 163,00±50,98; dan 205,80±106,44. Rerata kadar SGPT kelompok C dan SGOT kelompok D lebih rendah pada kelompok studi. Hasil uji Kruskal-Wallis menunjukkan tidak terdapat perbedaan bermakna secara signifikan kadar SGOT dan SGPT (p>0,05) diantara kelompok uji. Pada penelitian ini ekstrak etanol daun sendok meghambat peningkatan kadar SGOT dan SGPT model tikus hepatotoksik.

Abtrak (Bhs. Inggris)

Hepatotoxicity which caused by paracetamol induction was N-acetyl-p-benzoquinoneimine (NAPQI) toxic metabolite. This metabolite stimulated oxidative stress which induced hepatocyte damage by increasing the SGOT (Serum Glutamic-Oxaloacetic Transminase) dan SGPT (Serum Glutamic-Pyruvic Transminase). Ethanol extract of plantain (Plantago major L.) has antioxidant and antiinflammation agent. This study was to evaluate the effect of ethanol extract of Plantago major L. on reduction of SGOT and SGPT in paracetamol induced hepatotoxicity rat (Rattus norvegicus) model. The design method was experimental study and post test only with control group design. 25 rats male (Rattus norvegicus) were divided in to 5 group. Group A as a normal control was given aquades. Group B as a negative control was given paracetamol 128mg/200gBW rat/day per oral. Group C, D, and E were given paracetamol 128mg/200gBW rat/day per oral and ethanol extract of Plantago major L. 100mg, 200mg, and 400mg/200gBW rat/day per oral. The mean of SGPT level in five groups A, B, C, D and E are 86,80±10,01; 118,80±24,42; 98,60±9,40; 116,00±49,68; and 168,20±121,99. Whereas, the mean of SGOT level in five groups A, B, C, D and E are 164,80±21,95; 201,40±53,94; 165,60±10,29; 163,00±50,98; dan 205,80±106,44. The mean level of SGPT in group C and SGOT level of group D was lower in the study group.The results of Kruskal-Wallis test showed that there were not significantly differences of SGOT and SGPT (p>0,05) between the groups. This research can be concluded administration of ethanol extract of Plantago major L. can prevent the liver damage on reduction SGOT and SGPT level in drug induced hepatotoxicity rat (Rattus norvegicus) model.

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