Update Artikelilmiah: 13789

ARVIN LUTFIANI

NIM

Judul Artikel

Abstrak (Bhs. Indonesia)

Latar belakang: Karsinoma kolorektal adalah tumor ganas sistem pencernaan berlokasi di kolon atau rektum. Gen p53 adalah gen penekan tumor yang berperan dalam karsinogenesis kolorektal. Dari penelitian ini akan diketahui profil ekspresi p53 serta klinikopatologik penderita karsinoma kolorektal di Wilayah Banyumas. 
Tujuan: Mengetahui profil ekspresi p53 dan klinikopatologik berupa jenis kelamin, usia, topografi, Stadium Dukes, dan diferensiasi histopatologi penderita karsinoma kolorektal di Wilayah Banyumas.
Metode: Metode penelitian menggunakan deskriptif observasional. Klinikopatologik diteliti dari 57 kasus di RSMS dan RSUD Banyumas periode 2014 dan 45 sampel diambil untuk pemeriksaan imunohistokimia p53 menggunakan skor Allred. Analisis statistik menggunakan statistik deskriptif. 
Hasil: Profil ekspresi p53 20% positif. Klinikopatologik berdasarkan jenis kelamin menunjukkan laki-laki sebesar 56,1% dan perempuan 43,9%, berdasarkan usia ≤40 tahun 19,3% dan >40 tahun 80,7%, berdasarkan topografi 40,4% kolon proksimal dan 59,6% kolon distal, berdasarkan Stadium Dukes, 0% Dukes A, 70,2% Dukes B, 17,5% Dukes C, dan 12,3% Dukes D, berdasarkan diferensiasi histopatologi 84,2% baik, 14% moderat, dan 1,8% buruk. 
Kesimpulan: Profil ekspresi p53 20% positif dengan klinikopatologik terbanyak yaitu jenis kelamin laki-laki, usia >40 tahun, topografi di kolon distal, Stadium Dukes B, dan diferensiasi histopatologi baik pada karsinoma kolorektal di Wilayah Banyumas.

Abtrak (Bhs. Inggris)

Background: Colorectal carcinoma is a malignant tumor of the digestive system located in the colon or rectum. p53 gene is a tumor suppressor gene that plays a role in colorectal carcinogenesis. From this study will be known p53 expression and clinicopathologic profile patients of colorectal carcinoma in Banyumas region.
Objective: This study aimed to determine the expression of p53 and clinicopathologic profile such as gender, age, topography, Dukes Stage, and histopathological differentiation of colorectal carcinoma patients in Banyumas region.
Methods: Descriptive observational research method was used. Clinicopathologic study was taken from 57 cases in RSMS and Banyumas Hospital in 2014 and 45 samples were taken for p53 immunohistochemical examination scored by Allred Score. Descriptive statistics was used to analize the study.
Results: The expression of p53 positive 20%. Clinicopathological by gender showed 56,1% male and 43,9% female, by age 19,3% ≤40 years and 80,7% >40 years, based on topography were 40,4% in proximal colon and 59,6% in distal colon, based on Dukes Stage, 0% Dukes A, 70,2% Dukes B, 17,5% Dukes C and 12,3% Dukes D, based on histopathological differentiation were 84,2% well, 14% moderate, and 1,8% poor.
Conclusion: The expression of p53 positive was 20% with the highest clinicopathologic in male, age >40 years, topography in the distal colon, Dukes Stage B, and well histopathological differentiation.

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