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Abstrak (Bhs. Indonesia)

Ekstrak etanolik daun pegagan (Centella asiatica) pada tikus diabetes mellitus tipe 2 telah terbukti memiliki efek antidislipidemia. Kandungan flavonoid ekstrak daun pegagan mampu menurunkan kadar kolesterol total dan trigliserida, serta dapat meningkatkan kadar HDL. Penelitian ini bertujuan untuk mengetahui efek penurunan kadar kolesterol total dan trigliserida, serta peningkatan kadar HDL fraksi tidak larut kloroform (FTLK) ekstrak etanolik daun pegagan.
Penelitian ini merupakan penelitian eksperimental dengan menggunakan rancangan pre and post test control group design. Uji in vivo dilakukan dengan membagi 25 ekor tikus menjadi 5 kelompok, yaitu kelompok kontrol negatif Na-CMC 0,5%, kontrol positif simvastatin 0,9 mg/kgBB/hari, dan tiga kelompok perlakuan FTLK dosis berulang 250, 500, 750 mg/KgBB. Tikus diinduksi diet tinggi karbohidrat tinggi lemak (TKTL) selama 77 hari dengan perlakuan sediaan uji selama 7 hari. Pada hari ke-0, 71, dan 78 dilakukan pengambilan darah dan pemeriksaan kadar kolesterol total, trigliserida, dan HDL. Persen penurunan kadar kolesterol total dan trigliserida serta peningkatan kadar HDL dianalisis statistik dengan ANOVA satu arah dan dilanjutkan uji LSD. Serta dilakukan uji Paired T-test.
Hasil penelitian menunjukkan bahwa FTLK terbukti mampu meningkatkan kadar HDL secara signifikan. Namun perlakuan FTLK pada semua dosis belum mampu menurunkan kadar kolesterol total dan trigliserida secara bermakna pada tikus yang diinduksi diet TKTL.

Abtrak (Bhs. Inggris)

Ethanolic leaf extract of pegagan (Centella asiatica) in rats with type 2 diabetes mellitus has been shown to have an effect antidyslipidemia. Pegagan leaf extract flavonoid content could reduce level of total cholesterol and triglyceride, and also able to increase HDL level. This study aimed to determine the effect of a decrease in total cholesterol and triglyceride  level and also the increase in HDL level in chloroform insoluble fraction (CIF) of pegagan leaf ethanolic extract.
This study was an experimental study using pre and post-test control group design. This In vivo test was done by divided 25 rats in 5 group, they are negative control group (Na-CMC 0,5%), simvastatin 0.9 mg/KgBW/day positive control group, and three CIF repeated doses of 250, 500, 750 mg/KgBW treatment groups. Rats induced with high-carbohydrate high-fat diet (HCHF) for 77 days with preparation test treatment for 7 days. On day 0, 71, and 78 blood is sampled and total cholesterol, triglycerides, and HDL are inspected. Percentage decrease in total cholesterol and triglycerides level and also the percentage increase in HDL level were analyzed statistically by one-way ANOVA followed by LSD. And also paired t-test is performed.
Result of the research showed that CIF proven to increase HDL level were significantly. However CIF treatment at all doses have not been able to reduce total cholesterol and triglyceride level significantly in rats induced HFHC diet.

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