Update Artikelilmiah: 11089

WEDHA JATI TYAS SURYA UTAMA

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Abstrak (Bhs. Indonesia)

Latar Belakang : Tuberkulosis merupakan penyakit infeksi menular yang disebabkan oleh Mycobacterium tuberculosis. Pengobatan Tuberkulosis yang efektif telah tersedia, namun kasus Tuberkulosis masih menjadi faktor perhatian dunia. Salah satu terapi Tuberkulosis yang digunakan dalam program pemberantasan Tuberkulosis pada umumnya adalah metode multidrug yaitu menggunakan Obat Anti Tuberkulosis secara bersamaan. Efek samping berbahaya yang menjadi fokus saat ini adalah efek Obat Anti Tuberkulosis terhadap hepar, yaitu menyebabkan hepatotoksisitas yang ditunjukkan dengan pemeriksaan laboratorium darah meliputi pemeriksaan kadar Aspartate Amino Transaminase dan Alanine Amino Transferase.
Tujuan Penelitian : Mengetahui perbedaan kadar Aspartate Amino Transaminase dan Alanine Amino Transferase pada pasien Tuberkulosis Paru Kasus Baru antara sebelum dan sesudah menjalani terapi Obat Anti Tuberkulosis selama 1 bulan di RSUD Prof. dr. Margono Soekarjo Purwokerto periode September-Desember 2014.
Metode : Rancangan penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif observasional dengan pendekatan cross sectional. Data penelitian menggunakan data sekunder berupa rekam medik. Dilakukan uji statistik antara kadar Aspartate Amino Transaminase dan Alanine Amino Transferase pada pasien Tuberkulosis Paru kasus baru antara sebelum dan sesudah menjalani terapi Obat Anti Tuberkulosis selama 1 bulan.
Hasil : hasil uji Wilcoxon pada variabel mempunyai nilai p = 0,000 (p<0,05). Maka terdapat perbedaan kadar Aspartate Amino Transaminase dan Alanine Amino Transferase pada pasien Tuberkulosis Paru Kasus Baru antara sebelum dan sesudah menjalani terapi Obat Anti Tuberkulosis selama 1 bulan di RSUD Prof. dr. Margono Soekarjo Purwokerto periode September-Desember 2014.
Kesimpulan : Terdapat perbedaan kadar Aspartate Amino Transaminase dan Alanine Amino Transferase pada pasien Tuberkulosis Paru Kasus Baru antara sebelum dan sesudah menjalani terapi Obat Anti Tuberkulosis selama 1 bulan di RSUD Prof. dr. Margono Soekarjo Purwokerto periode September-Desember 2014.

Abtrak (Bhs. Inggris)

Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Effectiveness Tuberculosis treatment has been available, but Tuberculosis cases still have attention in the worldwide. One of Tuberculosis therapy used in the Tuberculosis eradication program in general is a method that uses Directly Observed Therapy multidrug simultaneously. Drugs toxicity side effects that the current focus is on the effect of hepatic Directly Observed Therapy, which causes hepatotoxicity indicated by laboratory tests include checking blood levels of Aspartate Amino Transaminase and Alanine Amino Transferase.
Objective: To cognize the different of Aspartate Amino Transaminase and Alanine Amino Transferase. levels in patients with primary pulmonary Tuberculosis between before and after Directly Observed Therapy for 1 month in Prof. dr. Margono Soekarjo Purwokerto hospitals in the period from September to December, 2014.
Methods: The research design used descriptive observational study with cross sectional approach. Data research using secondary data from medical records. Do statistic between the levels of Aspartate Amino Transaminase and Alanine Amino Transferase in levels in patients with primary pulmonary Tuberculosis on between before and after Directly Observed therapy for 1 month.
Results: The results of the Wilcoxon Sign Rank test on the variable has a value of p = 0.000 (p <0.05). Then there are differences in the levels of Aspartate Amino Transaminase and Alanine Amino Transferase. In patients with primary pulmonary Tuberculosis between before and after therapy for 1 month Directly Observed Therapy in Prof. dr. Margono Soekarjo Purwokerto hospitals period from September to December, 2014.
Conclusions: There are differences levels of Aspartate Amino Transaminase and Alanine Amino Transferase. In patients with primary pulmonary Tuberculosis between before and after therapy for 1 month Directly Observed Therapy in Prof. dr. Margono Soekarjo Purwokerto hospitals the September to December 2014.

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