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CORNELLA PRISCKE SILVANA

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Abstrak (Bhs. Indonesia)

Latar  Belakang  :  Penyakit  Jantung  Koroner  (PJK)  merupakan  salah  satu penyebab utama kematian di negara maju dan  berkembang yang erat kaitannya dengan  kadar  LDL.  Terapi  menurunkan  kadar  LDL  melalui  farmakologis cenderung menimbulkan efek samping sehingga perlu terapi lain berbentuk obat tradisional  khususnya  biji  kurma.  Biji  kurma  mengandung  pektin,  fenolik, kuersetin dan vitamin C yang dapat menurunkan kadar LDL dalam darah. 
Tujuan  :  Mengetahui  pengaruh  pemberian  ekstrak  biji  kurma  (Phoenix Dactylifera L)  terhadap kadar LDL darah pada tikus putih  model  diet  tinggi lemak. 
Metode : Penelitian ini adalah penelitian eksperimental dengan desain rancangan acak lengkap dan pendekatan pre and post with control group design. Tiga puluh enam  tikus  putih  galur  wistar  dengan  berat  badan  ±200g  dibagi  menjadi  6 kelompok.  Kelompok  A  (kontrol  negatif)  diberikan  Normal  Fat  Diet  (NFD), Kelompok B (kontrol positif) diberikan High Fat Diet (HFD), kelompok C,D dan E  diberikan  HFD  dan  ekstrak  biji  kurma  dosis  bertingkat  dan  kelompok  F diberikan HFD dan simvastatin. Kadar LDL diperiksa pada awal perlakuan dan akhir perlakuan  selama 7 hari. Hasil  pemeriksaan dianalisis menggunakan uji analysis of variance (ANOVA) dengan Post Hoc Duncan. 
Hasil : Hasil rerata selisih kadar LDL kelompok D (25,9 ± 11,1) lebih tinggi dari pada  kelima  kelompok  lainnya.  Kelompok  E  memiliki  rerata  LDL  posttest tertinggi berbeda bemakna terhadap kelompok B (p<0,05). Selisih kadar LDL pre-post kelompok D dan E   berbeda  bermakna terhadap kelompok A (p<0,05), sedangkan  kadar  LDL  pre-post  kelompok  C  dan  F  tidak  berbeda  bermakna terhadap kelompok A (p>0,05). 
Kesimpulan : Ekstrak biji kurma berpengaruh terhadap penurunan kadar LDL pada tikus model diet tinggi lemak dengan dosis efektif 500 mg/KgBB. 
Kata Kunci : Ekstrak Biji Kurma, LDL, Simvastatin

Abtrak (Bhs. Inggris)

Background : Coronary Heart Disease (CHD) is one of main causes of death in eveloped  and  developing  countries  that  have  close  relationship  with  LDL cholesterol levels. Therapy to decrease LDL levels by pharmacological likely can cause side effects, so traditional drug was needed especially date seed. Date seeds contain pectin, phenolic, quersetin and vitamin C that can reduce levels of LDL blood levels. 
Objective : The purpose of this study was to determine the effect of date seed extract (Phoenix dactylifera L.) on LDL levels in high fat diet rats models. 
Methods :  This  study  is  an  experimental  research  design  with  a  completely 
randomized design and approach to pre and post with control group design. 36 Wistar strain rats with weight ±200 g were divided  into 6 groups. Group A (negative control) was given Normal Fat Diet (NFD), Group B (positive control) was given the High Fat Diet (HFD), group C, D and E were given HFD and date seed extract with 3 levels dose and group F was given HFD and simvastatin. LDL levels checked at the beginning and end of treatment for 7 days. Results test were analyzed using analysis of variance test (ANOVA) with Post Hoc duncan. 
Results : Delta mean in LDL cholesterol group D (25.9 ± 11.1) was higher than the  five other groups.  Group E has the  highest posttest mean LDL different significant against group B (p <0.05). Delta LDL levels group D and E was significantly to group A (p <0.05), but Delta LDL levels group C and F not significantly to group A (p>0,05). 
Conclusion : There was an effect of administering date seed extract in lowering high-fat diet rats models LDL levels with effectiveness dose of 500 mg/KgBW 
Keywords : Date Seed Extract, LDL, Simvastatin

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